Trichomonasvirus (taxid:674952)



Non enveloped, icosahedral virion composed of a single capsid protein (CP), about 36 nm in diameter. The capsid has a T=2* icosahedral symmetry.



Monopartite, linear dsRNA genome of 4.6-4.9 kb. The genome has two large, overlapping ORFs on the positive strand encoding the capsid (gag) and polymerase (pol) proteins.


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a mRNA, which is translocated to the cell cytoplasm where it is translated.
Translation is initiated on a unique internal ribosome entry site (IRES) element situated at the 5'-UTR.
The plus-strand viral transcript is flanked by a 5'untranslated region (5'-UTR) and a 3'-UTR and directs the translation of a major CP (Gag) and a minor fusion protein CP-RdRP (Gag-Pol) via a +1 or -2 ribosomal frameshift.




  1. Cell to cell transmission of the virus through small extracellular vesicles.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released from the host cell.
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Trichomonas vaginalis virus 1 taxid:674953

Protein ModelArchive
Capsid protein ma-jd-viral-62208
Capsid protein ma-jd-viral-62208
RNA-directed RNA polymerase (EC ma-jd-viral-32338

Trichomonas vaginalis virus 2 taxid:674954

Protein ModelArchive
Capsid protein ma-jd-viral-62207
RNA-directed RNA polymerase (EC ma-jd-viral-32339