Modulation of host ubiquitin pathway by viral E3 ligase

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The E3 ubiquitin ligase operates in conjunction with an E1 ubiquitin-activating enzyme and an E2 ubiquitin-conjugating enzyme and transfers ubiquitin to the target substrate. Two types of E3 ubiquitin ligases are present in cells based on the structure of their catalytic domain named RING and HECT. The E3s polyubiquitinate target proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Several viruses encode viral E3 ligases in order to direct specific substrates for proteasomal degradation. For example, herpes simplex virus encodes ICPO which acts as a nuclear E3 ubiquitin ligase that polyubiquitinates the nuclear bodies-associated PML and Sp100 proteins.

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by strain (browse by keywords)

2 entries

Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain

Select_allDeselect_all
VIE2_NPVOP E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...
IAP3_NPVOP E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)

2 entries

White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

Select_allDeselect_all
UB222_WSSVS RING finger containing E3 ubiquitin-protein ligase WSV222 (EC 2.3.2.27) (RING-type E3 ubiquitin ...
UB403_WSSVS RING finger containing E3 ubiquitin-protein ligase WSV403 (EC 2.3.2.27) (RING-type E3 ubiquitin ...

1 entry

Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

IE2_NPVAC E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain

IE61_CHV9D E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)

1 entry

Cowpox virus (strain Brighton Red) (CPV) reference strain

P28_CWPXB E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein CPXV023) (RING-type E3 ubiquitin ...

1 entry

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

ICP0_EHV1B E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E434_ADE02 Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

ICP0_HHV11 E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) ...

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP0_HHV2H E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 ...

1 entry

Hyphantria cunea nuclear polyhedrosis virus (HcNPV) reference strain

VIE2_NPVHC E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Myxoma virus (strain Lausanne) (MYXV) reference strain

LAP_MYXVL E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

LAP_RFVKA E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV) reference strain

VIE2_NPVR1 E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

IE61_VZVD E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ...

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

P28_VAR67 E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (D4R protein) (RING-type E3 ubiquitin transferase ...

1 entry

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

LAP_YMTV5 E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Yaba-like disease virus (YLDV) reference strain

LAP_YLDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Bombyx mori nuclear polyhedrosis virus (BmNPV)

VIE2_NPVBM E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1J E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)

ICP0_BHV1K E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ...

1 entry

Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV)

VIE2_NPVCF E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin ...

1 entry

Cowpox virus (strain GRI-90 / Grishak) (CPV)

P28_CWPXG E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein C7R) (RING-type E3 ubiquitin transferase ...

1 entry

Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

P28_ECTVM E3 ubiquitin-protein ligase p28 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

1 entry

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

ICP0_EHV1V E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin ...

1 entry

Lumpy skin disease virus (LSDV)

LAP_LSDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Monkeypox virus (strain Zaire-96-I-16) (MPX)

P28_MONPZ E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein D5R) (RING-type E3 ubiquitin transferase ...

1 entry

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

ICP0_SUHVF E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin ...

1 entry

Swinepox virus (strain Kasza) (SWPV)

LAP_SWPVK E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Vaccinia virus (strain LC16m0) (VACV)

P28_VACC0 E3 ubiquitin ligase p28-like (EC 2.3.2.-) (E3 ubiquitin transferase p28-like)

1 entry

Vaccinia virus (strain LC16m8) (VACV)

P28_VACC8 E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)