Modulation of host E3 ubiquitin ligases by virus

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The E3 ubiquitin ligase operates in conjunction with an E1 ubiquitin-activating enzyme and an E2 ubiquitin-conjugating enzyme and transfers ubiquitin to the target substrate. Two types of E3 ubiquitin ligases are present in cells based on the structure of their catalytic domain named RING and HECT. The E3s polyubiquitinate target proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Several viruses encode viral E3 ligases in order to direct specific substrates for proteasomal degradation. For example, herpes simplex virus encodes ICPO which acts as a nuclear E3 ubiquitin ligase that polyubiquitinates the nuclear bodies-associated PML and Sp100 proteins.

Matching UniProtKB/Swiss-Prot entries

25 entries grouped by strain (browse by keywords)

3 entries

Cowpox virus (strain Brighton Red) (CPV) reference strain

Select_allDeselect_all
KBTB2_CWPXB Kelch repeat and BTB domain-containing protein 2
KBTB1_CWPXB Kelch repeat and BTB domain-containing protein 1
CP77_CWPXB Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

1 entry

Camelpox virus (strain CMS) reference strain

KBTB1_CAMPS Kelch repeat and BTB domain-containing protein 1

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1A_ADE02 Early E1A protein (Early E1A 32 kDa protein)

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

E1A_ADE05 Early E1A protein (Early E1A 32 kDa protein)

1 entry

Myxoma virus (strain Lausanne) (MYXV) reference strain

MT5_MYXVL Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)

1 entry

Simian virus 40 (SV40) reference strain

LT_SV40 Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

KBTB1_VACCW Kelch repeat and BTB domain-containing protein A55

2 entries

Cowpox virus (strain GRI-90 / Grishak) (CPV)

Select_allDeselect_all
KBTB2_CWPXG Kelch repeat and BTB domain-containing protein 2
KBTB1_CWPXG Kelch repeat and BTB domain-containing protein 1

2 entries

Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

Select_allDeselect_all
KBTB2_ECTVM Kelch repeat and BTB domain-containing protein 2
KBTB1_ECTVM Kelch repeat and BTB domain-containing protein 1

2 entries

Horsepox virus (HSPV)

Select_allDeselect_all
KBTB1_HSPV Kelch repeat and BTB domain-containing protein 1
KBTB2_HSPV Kelch repeat and BTB domain-containing protein 2

1 entry

Cowpox virus (CPV)

CP77_COWPX Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

LMP2_EBVG Latent membrane protein 2 (Terminal protein)

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)

1 entry

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

E1A_ADE07 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

E1A_ADE04 Early E1A protein (Early E1A 28 kDa protein)

1 entry

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

E1A_ADE40 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

E1A_ADE41 Early E1A protein (Early E1A 27 kDa protein)

1 entry

Vaccinia virus (strain Copenhagen) (VACV)

KBTB1_VACCC Kelch repeat and BTB domain-containing protein 1