Dicistroviridae (taxid:232795)



Non enveloped, pseudo T=3 icosahedral capsid, about 30 nm in diameter.



Monopartite, linear ssRNA(+) genome of 8.5-10.2 kb, with a VPg bound at the 5'-terminus and a 3'-polyA tract. Contains two non-overlapping open reading frames, ORF1 and ORF2, which respectively encode the nonstructural and structural proteins.


The virion RNA is infectious and serves as both genome and mRNA. The genome ORF1 and ORF2 encode two polyproteins, the first of which contains the non-structural proteins involved in replication, while the second, contains three (or more) capsid proteins. Each ORF is preceded by one internal ribosome entry site (IRES) located at the 5' end and in the middle of the mRNA.
Ribosomal skipping may also be used to express viral protein 1A from ORF1 of cricket paralysis virus.



  1. Virus penetrates into the cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein RNA1.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the RNA2 polyprotein (structural proteins).
  7. virus release (or cell-cell spread of viral RNAs?).

Host-virus interaction

Host gene expression shutoff by virus

CrPV infection results in host translation shutoff concomitant with an increase in viral protein synthesis via CrPV internal ribosome entry sites (IRES). Host translation shutoff involves the dissociation of eIF4G and eIF4E .

Suppression of RNA silencing

Drosophila C virus protein DCV-1A and Cricket paralysis virus protein CrPV-1A function as suppressor of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

6 entries grouped by protein

1 entry

Putative protein pog (ORFx protein)

Acute bee paralysis virus (strain Rothamsted) (ABPV) reference strain

3 entries

Replicase polyprotein (EC (EC 3.4.22.-)

Acute bee paralysis virus (strain Rothamsted) (ABPV) reference strain
Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV) reference strain

Replicase polyprotein

Drosophila C virus (strain EB) (DCV)

Replicase polyprotein

2 entries

Structural polyprotein

Acute bee paralysis virus (strain Rothamsted) (ABPV) reference strain
Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Acute bee paralysis virus (strain Rothamsted) taxid:1217067

Protein ModelArchive
Structural polyprotein ma-jd-viral-08840

Anopheles C virus taxid:1769780

Protein ModelArchive
Structural polyprotein ma-jd-viral-08858

Black queen cell virus taxid:92395

Protein ModelArchive
Structural polyprotein ma-jd-viral-08679

Centovirus AC taxid:1916650

Protein ModelArchive
Capsid ma-jd-viral-08864

Formica exsecta virus 1 taxid:1432856

Protein ModelArchive
Structural protein ma-jd-viral-08862

Himetobi P virus taxid:81583

Protein ModelArchive
Capsid protein ma-jd-viral-08871

Macrobrachium rosenbergii Taihu virus taxid:1027947

Protein ModelArchive
Capsid protein ma-jd-viral-08850

Mosquito dicistrovirus taxid:1911442

Protein ModelArchive
Capsid ma-jd-viral-08832

Mud crab virus taxid:932662

Protein ModelArchive
Structural polyprotein ma-jd-viral-08861

Plautia stali intestine virus taxid:64698

Protein ModelArchive
Capsid protein ma-jd-viral-08824

Solenopsis invicta virus 1 taxid:294369

Protein ModelArchive
Nonstructural polyprotein ma-jd-viral-00291
Structural polyprotein ma-jd-viral-08833

Taura syndrome virus taxid:142102

Protein ModelArchive
Capsid protein ma-jd-viral-08843

Triatoma virus taxid:103442

Protein ModelArchive
Capsid protein ma-jd-viral-08828