Turncurtovirus (taxid:1298631)



Non-enveloped, twinned (geminate) incomplete T=1 icosahedral symmetry capsid that contains 22 pentameric capsomers made of 110 capsid proteins (CP). Each geminate particle contains only a single circular ssDNA.



Monopartite, circular, ssDNA genome (+) genome of about 3.0 kb. 3' terminus has no poly(A) tract. There are coding regions in both the virion (positive) and complementary (negative) sense strands.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates and terminates rolling circle replication, the host DNA polymerase being used for DNA replication itself. There is a potential stem-loop structure in the intergenic region where ssDNA synthesis is initiated.


Transcription is bidirectional from the intergenic region. 6 proteins are produced. On the v-sense: Movement protein (MP) and CP protein. On the C-sense: Rep, C2, C3 and C4.
Proteins are expressed from subgenomic RNAs (sgRNAs).




  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors.
  4. bidirectional dsDNA transcription from the IR promoter produces viral mRNAs and translation of viral proteins.
  5. Replication is initiated by cleavage of the(+)strand by REP, and occurs by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis
    c) be transported outside the nucleus, to a neighboring cell through plasmodesmata (cell-cell movement) with the help of viral movement proteins.

Host-virus interaction

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Turnip curly top virus taxid:859650

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27729
V2 ma-jd-viral-36572

Turnip leaf roll virus taxid:1766828

Protein ModelArchive
C2 ma-jd-viral-54069
C4 ma-jd-viral-45394
Capsid protein (Coat protein) ma-jd-viral-27725
Replication enhancer (REn) ma-jd-viral-03465
Replication-associated protein (Rep) (EC 3.1.21.-) ma-jd-viral-20242
V2 ma-jd-viral-36573