Muromegalovirus (taxid:10365)



Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.


Monopartite, linear, dsDNA genome of about 230 kb predicted to encode more than 170 open reading frames. The genome contains terminal and internal reiterated sequences.


Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.




Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Mouse cytomegalovirus (MCMV) uses m152 and m06 encoded proteins to inhibit surface expression of MHC I molecules .

Apoptosis modulation

Murine cytomegalovirus m38.5 protein interacts with host Bax in infected cells and thus inhibits Bax-mediated cell death . The m36 gene product termed M-vICA plays also a role in cell death suppression .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. MCMV encodes an UL24 homolog that performs this role . In addition, the IE3 protein is able to arrest cell cycle in G1/S transition or in G2/M.

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein. The m157 protein delivers inhibitory signals to NK cell subsets expressing Ly49I or Ly49I-like inhibitory receptors. Another protein, m04 forms complexes with MHC I and escorts them to the cell surface. This mechanism prevents NK cell activation by restoring the "self" signature and allowing the engagement of inhibitory Ly49 receptors on NK cells. Four other MCMV proteins m145, m152, m155 and m138 are involved in the down-modulation of NKG2D ligand expression.

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to website)

24 entries grouped by strain

15 entries

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain

RIR1_MUHVS Ribonucleoside-diphosphate reductase large subunit-like protein (Viral inhibitor of RIP activation) ...
GB_MUHVS Envelope glycoprotein B (gB)
DPOL_MUHVS DNA polymerase catalytic subunit (EC
DNBI_MUHVS Major DNA-binding protein
GH_MUHVS Envelope glycoprotein H (gH)
GL_MUHVS Envelope glycoprotein L (gL)
GN_MUHVS Envelope glycoprotein N
DUT_MUHVS Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC (dUTP pyrophosphatase)
ICP27_MUHVS mRNA export factor ICP27 homolog
UL33_MUHVS G-protein coupled receptor homolog M33
VIE1_MUHVS Immediate-early protein 1 (IE1) (Immediate-early phosphoprotein PP89)
VIE2_MUHVS Immediate-early protein 2 (IE2)
VIE3_MUHVS Immediate-early protein 3 (IE3)
TRM1_MUHVS Tripartite terminase subunit 1
PRIM_MUHVS DNA primase (EC 2.7.7.-)

3 entries

Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus) reference strain

LTP_MUHVK Large tegument protein deneddylase (EC (EC 3.4.22.-)
CEP3_MUHVK Cytoplasmic envelopment protein 3
M35_MUHVK Protein M35

2 entries

Rat cytomegalovirus (strain Maastricht) reference strain

UL33_RCMVM G-protein coupled receptor homolog R33
DPOL_RCMVM DNA polymerase catalytic subunit (EC

1 entry

Rat cytomegalovirus (isolate England) (RCMV-E) (Murid herpesvirus 8) reference strain

VXCL1_RCMVE Viral Lymphotactin (Viral XCL1) (vSCL1)

1 entry

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)

UL97_MUHVS Serine/threonine protein kinase M97 (EC

2 entries

Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)

GM_MUHVK Envelope glycoprotein M (gM)
GL_MUHVK Envelope glycoprotein L (gL)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Murid herpesvirus 1 taxid:10366

Protein ModelArchive
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12515
Cytomegalovirus Smith HindIII J ma-jd-viral-66039
Cytoplasmic envelopment protein 3 ma-jd-viral-63892
M06 protein ma-jd-viral-20124
M100 protein ma-jd-viral-37895
M104 protein ma-jd-viral-59312
M114 protein ma-jd-viral-07742
M119.2 protein ma-jd-viral-35139
M119.3 protein ma-jd-viral-42111
M119.4 protein ma-jd-viral-66546
M119.5 protein ma-jd-viral-61595
M120 protein ma-jd-viral-53567
M124 protein ma-jd-viral-51486
M124.1 protein ma-jd-viral-35332
M126 protein ma-jd-viral-51866
M140 protein ma-jd-viral-13159
M142 protein ma-jd-viral-13147
M147 protein ma-jd-viral-54441
M148 protein ma-jd-viral-36519
M152 protein ma-jd-viral-17726
M157 ma-jd-viral-17701
M23 protein ma-jd-viral-13011
M23.1 protein ma-jd-viral-37078
M24 protein ma-jd-viral-13099
M37 protein ma-jd-viral-48963
M39 protein ma-jd-viral-33562
M41 protein ma-jd-viral-51192
M42 protein ma-jd-viral-32774
M46 protein ma-jd-viral-09117
M50 protein ma-jd-viral-12379
M53 protein ma-jd-viral-10221
M56 protein ma-jd-viral-61466
M69.1 protein ma-jd-viral-59101
M72 protein ma-jd-viral-12735
M73 protein ma-jd-viral-37417
M84 protein ma-jd-viral-12786
M85 protein ma-jd-viral-04790
M87 protein ma-jd-viral-56112
M88 protein ma-jd-viral-10975
M91 protein ma-jd-viral-30445
M92 protein ma-jd-viral-51368
M94 protein ma-jd-viral-02712
M96 protein ma-jd-viral-46353
ORF HJ1 ma-jd-viral-16812
ORF HJ3 ma-jd-viral-56468
ORF HJ4 ma-jd-viral-33742
ORF HJ5 ma-jd-viral-50155
ORF HJ6 ma-jd-viral-45730
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Phosphotransferase ma-jd-viral-24849
Small capsomere-interacting protein ma-jd-viral-64656
Tegument protein UL51 homolog ma-jd-viral-02727

Murid herpesvirus 1 (strain Smith) taxid:10367

Protein ModelArchive
Cytoplasmic envelopment protein 3 ma-jd-viral-63892
DNA helicase ma-jd-viral-37535
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-34358
Envelope glycoprotein L (gL) ma-jd-viral-00358
Envelope glycoprotein L (gL) ma-jd-viral-00358
Exonuclease ma-jd-viral-08469
Fc receptor glycoprotein fcr1 ma-jd-viral-45730
Glycoprotein M ma-jd-viral-37895
Glycoprotein family protein m02 ma-jd-viral-20123
Glycoprotein family protein m07 ma-jd-viral-43560
Glycoprotein family protein m08 ma-jd-viral-20129
Glycoprotein family protein m09 ma-jd-viral-20128
Glycoprotein family protein m10 ma-jd-viral-20130
Glycoprotein family protein m11 ma-jd-viral-20122
Glycoprotein family protein m12 ma-jd-viral-20126
Glycoprotein family protein m13 ma-jd-viral-57102
Glycoprotein family protein m14 ma-jd-viral-35957
Glycoprotein family protein m15 ma-jd-viral-20127
Glycoprotein family protein m16 ma-jd-viral-20125
Helicase-primase component ma-jd-viral-17343
ICP18.5-like protein ma-jd-viral-61466
IE glycoprotein ma-jd-viral-48963
MGP family protein m145 ma-jd-viral-17732
MGP family protein m146 ma-jd-viral-17708
MGP family protein m150 ma-jd-viral-17725
MGP family protein m151 ma-jd-viral-17733
MGP family protein m152 ma-jd-viral-17726
MGP family protein m153 ma-jd-viral-17728
MGP family protein m155 ma-jd-viral-17685
MGP family protein m157 ma-jd-viral-17701
MGP family protein m158 ma-jd-viral-17690
MGP family protein m17 ma-jd-viral-17731
MHC class I-like protein ma-jd-viral-17692
Minor capsid protein ma-jd-viral-09117
Packaging protein UL32 ma-jd-viral-40948
Putative MGP ma-jd-viral-67117
Putative glycoprotein ma-jd-viral-32774
Putative glycoprotein ma-jd-viral-50155
Putative glycoprotein ma-jd-viral-54359
Putative membrane glycoprotein ma-jd-viral-31306
Putative membrane glycoprotein ma-jd-viral-41435
Putative membrane glycoprotein ma-jd-viral-64421
Putative membrane glycoprotein ma-jd-viral-66825
Putative membrane glycoprotein ma-jd-viral-57522
Putative membrane glycoprotein ma-jd-viral-56485
Putative membrane glycoprotein ma-jd-viral-61602
Putative membrane glycoprotein ma-jd-viral-59479
Putative membrane glycoprotein anchor ma-jd-viral-51641
Putative multiple membrane spanning protein ma-jd-viral-54441
Pyruvoyl decarboxylase-like protein ma-jd-viral-01768
Serine-alanine-rich glycoprotein ma-jd-viral-62874
Small capsomere-interacting protein ma-jd-viral-64656
Structural protein ma-jd-viral-59312
Tegument protein ma-jd-viral-20001
Tegument protein UL51 homolog ma-jd-viral-02727
Threonine-serine-rich glycoprotein ma-jd-viral-33080
UL25 family protein ma-jd-viral-07647
UL25 family protein ma-jd-viral-57608
US22 family protein ma-jd-viral-13011
US22 family protein ma-jd-viral-13054
US22 family protein ma-jd-viral-13078
US22 family protein ma-jd-viral-13099
US22 family protein ma-jd-viral-13130
US22 family protein ma-jd-viral-13132
US22 family protein ma-jd-viral-13147
US22 family protein ma-jd-viral-13151
US22 family protein ma-jd-viral-13159
Uncharacterized protein M103 ma-jd-viral-14100
Uncharacterized protein M121 ma-jd-viral-60673
Uncharacterized protein M26 ma-jd-viral-16111
Uncharacterized protein M27 ma-jd-viral-13324
Uncharacterized protein M28 ma-jd-viral-13041
Uncharacterized protein M34 ma-jd-viral-63958
Uncharacterized protein M38 ma-jd-viral-54324
Uncharacterized protein M51 ma-jd-viral-43898
Uncharacterized protein M76 ma-jd-viral-12169
Uncharacterized protein M85 ma-jd-viral-04790
Uncharacterized protein M87 ma-jd-viral-56112
Uncharacterized protein M88 ma-jd-viral-10975
Uncharacterized protein M91 ma-jd-viral-30445
Uncharacterized protein M92 ma-jd-viral-51368
Uncharacterized protein M93 ma-jd-viral-02108
Uncharacterized protein M95 ma-jd-viral-45149
Uncharacterized protein M96 ma-jd-viral-46353
Uncharacterized protein m106 ma-jd-viral-45602
Uncharacterized protein m119.2 ma-jd-viral-35139
Uncharacterized protein m119.3 ma-jd-viral-42111
Uncharacterized protein m119.4 ma-jd-viral-66546
Uncharacterized protein m119.5 ma-jd-viral-61595
Uncharacterized protein m120 ma-jd-viral-53567
Uncharacterized protein m123Ex2 ma-jd-viral-67473
Uncharacterized protein m124 ma-jd-viral-51486
Uncharacterized protein m124.1 ma-jd-viral-35332
Uncharacterized protein m125 ma-jd-viral-31122
Uncharacterized protein m126 ma-jd-viral-51866
Uncharacterized protein m127 ma-jd-viral-54656
Uncharacterized protein m128Ex3 ma-jd-viral-13052
Uncharacterized protein m129 ma-jd-viral-58939
Uncharacterized protein m130 ma-jd-viral-36043
Uncharacterized protein m131 ma-jd-viral-16812
Uncharacterized protein m134 ma-jd-viral-66039
Uncharacterized protein m135 ma-jd-viral-56468
Uncharacterized protein m136 ma-jd-viral-33742
Uncharacterized protein m148 ma-jd-viral-36519
Uncharacterized protein m149 ma-jd-viral-40402
Uncharacterized protein m156 ma-jd-viral-39004
Uncharacterized protein m168 ma-jd-viral-62493
Uncharacterized protein m169 ma-jd-viral-39461
Uncharacterized protein m170 ma-jd-viral-62250
Uncharacterized protein m19 ma-jd-viral-56483
Uncharacterized protein m21 ma-jd-viral-60548
Uncharacterized protein m22 ma-jd-viral-38982
Uncharacterized protein m23.1 ma-jd-viral-37078
Uncharacterized protein m25.1 ma-jd-viral-13133
Uncharacterized protein m25.4 ma-jd-viral-13028
Uncharacterized protein m39 ma-jd-viral-33562
Uncharacterized protein m40 ma-jd-viral-53557
Uncharacterized protein m41 ma-jd-viral-51192
Uncharacterized protein m48.1 ma-jd-viral-32003
Uracil DNA glycosylase-like protein ma-jd-viral-07742
mRNA export factor ICP27 homolog ma-jd-viral-64691

Rat cytomegalovirus (isolate England) taxid:1261657

Protein ModelArchive
B100 (E100) ma-jd-viral-37888
B103 (E103) ma-jd-viral-14094
B104 (E104) ma-jd-viral-59261
B114 (E114) ma-jd-viral-07740
B119.2 (E119.2) ma-jd-viral-35140
B127 (E127) ma-jd-viral-24357
B131 (E131) ma-jd-viral-62679
B138 (E138) ma-jd-viral-45729
B140 (E140) ma-jd-viral-13153
B141 (E141) ma-jd-viral-13156
B143 (E143) ma-jd-viral-13145
B149 (E149) ma-jd-viral-17703
B167 (E167) ma-jd-viral-66826
B168.5 (E168.5) ma-jd-viral-16400
B23 (E23) ma-jd-viral-13004
B24 (E24) ma-jd-viral-13112
B26 (E26) ma-jd-viral-16112
B27a (E27a) ma-jd-viral-13323
B28 (E28) ma-jd-viral-13044
B33 (E33) ma-jd-viral-18373
B34 (E34) ma-jd-viral-63959
B36 (E36) ma-jd-viral-13021
B37 (E37) ma-jd-viral-48964
B38.5 (E38.5) ma-jd-viral-39775
B39 (E39) ma-jd-viral-33561
B40 (E40) ma-jd-viral-53558
B41 (E41) ma-jd-viral-29924
B41.1 (E41.1) ma-jd-viral-43878
B42 (E42) ma-jd-viral-51187
B43 (E43) ma-jd-viral-13131
B46 (E46) ma-jd-viral-09121
B50 (E50) ma-jd-viral-12378
B51 (E51) ma-jd-viral-60375
B55 (E55) ma-jd-viral-31202
B56 (E56) ma-jd-viral-61515
B70 (E70) ma-jd-viral-33329
B72 (E72) ma-jd-viral-12734
B73 (E73) ma-jd-viral-37416
B73.5 (E73.5) ma-jd-viral-40229
B74 (E74) ma-jd-viral-29224
B75 (E75) ma-jd-viral-16942
B76 (E76) ma-jd-viral-12170
B78 (E78) ma-jd-viral-18433
B79 (E79) ma-jd-viral-54804
B82 (E82) ma-jd-viral-12788
B85 (E85) ma-jd-viral-04788
B87 (E87) ma-jd-viral-56106
B89 (E89) ma-jd-viral-06547
B90 (E90) ma-jd-viral-67116
B91 (E91) ma-jd-viral-47815
B92 (E92) ma-jd-viral-51379
B94 (E94) ma-jd-viral-02706
B95 (E95) ma-jd-viral-45155
B96 (E96) ma-jd-viral-46354
B97 (E97) ma-jd-viral-24845
BORF14 (EORF14) ma-jd-viral-49077
BORF4 (EORF4) ma-jd-viral-61554
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12485
Cytoplasmic envelopment protein 3 ma-jd-viral-63891
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-34352
E1.5 ma-jd-viral-16416
E102 ma-jd-viral-17351
E105 ma-jd-viral-37575
E112-113 ma-jd-viral-50730
E116.1 ma-jd-viral-53888
E117 ma-jd-viral-58394
E118 ma-jd-viral-24474
E119.1 ma-jd-viral-60629
E120.1 ma-jd-viral-35717
E121 ma-jd-viral-52005
E124a ma-jd-viral-51487
E128 ma-jd-viral-13050
E133 ma-jd-viral-51820
E135 ma-jd-viral-30407
E136 ma-jd-viral-33743
E137 ma-jd-viral-50154
E139 ma-jd-viral-13053
E142 ma-jd-viral-13152
E144 ma-jd-viral-17691
E152 ma-jd-viral-17694
E152.1 ma-jd-viral-17689
E152.2 ma-jd-viral-17704
E153 ma-jd-viral-17727
E153.1 ma-jd-viral-17693
E155 ma-jd-viral-17684
E155.1 ma-jd-viral-17729
E159 ma-jd-viral-56484
E160 ma-jd-viral-51203
E164 ma-jd-viral-64422
E166 ma-jd-viral-47102
E20 ma-jd-viral-67522
E25 ma-jd-viral-57609
E25.1 ma-jd-viral-13116
E25.2 ma-jd-viral-13029
E29.1 ma-jd-viral-16136
E31 ma-jd-viral-30430
E32 ma-jd-viral-20000
E35 ma-jd-viral-07649
E38 ma-jd-viral-54325
E47 ma-jd-viral-14840
E49 ma-jd-viral-40323
E53 ma-jd-viral-10224
E77 ma-jd-viral-01730
E83 ma-jd-viral-12770
E84 ma-jd-viral-12785
E88 ma-jd-viral-10988
E93 ma-jd-viral-02107
E98a ma-jd-viral-08465
EORF1 ma-jd-viral-44511
EORF10 ma-jd-viral-62368
EORF11 ma-jd-viral-42782
EORF12 ma-jd-viral-32877
EORF13 ma-jd-viral-29394
EORF15 ma-jd-viral-52541
EORF16 ma-jd-viral-56054
EORF17 ma-jd-viral-34465
EORF18 ma-jd-viral-31337
EORF2 ma-jd-viral-38786
EORF5 ma-jd-viral-67181
EORF6 ma-jd-viral-66917
EORF7 ma-jd-viral-17702
EORF8 ma-jd-viral-66580
EORF9 ma-jd-viral-45919
Envelope glycoprotein L (gL) ma-jd-viral-00359
Immediate early protein 1 ma-jd-viral-00821
Immediate early protein 2 ma-jd-viral-20056
Packaging protein UL32 ma-jd-viral-40969
Small capsomere-interacting protein ma-jd-viral-64663
Tegument protein UL51 homolog ma-jd-viral-02723
Viral Lymphotactin (Viral XCL1) (vSCL1) ma-jd-viral-16803
mRNA export factor ICP27 homolog ma-jd-viral-64690