Macavirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Apoptosis modulation

Alcelaphine herpesvirus 1 encodes a bcl-2 homologue that may inhibit host apoptosis.

Host splicing inhibition

Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

71 entries grouped by strain (browse by keywords)

All proteins are shown (view only 70 complete proteome entries)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_allDeselect_all
RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
UL32_ALHV1 Packaging protein UL32 homolog
VG23_ALHV1 Uncharacterized gene 23 protein
VG45_ALHV1 Uncharacterized gene 45 protein
VG59_ALHV1 DNA polymerase processivity factor
VG48_ALHV1 Uncharacterized gene 48 protein
VG11_ALHV1 Uncharacterized gene 11 protein
TRM1_ALHV1 Tripartite terminase subunit 1
UL92_ALHV1 Gene 31 protein
VG41_ALHV1 Uncharacterized gene 41 protein
VG58_ALHV1 Gene 58 protein
VGA2_ALHV1 Uncharacterized protein A2
VGA6_ALHV1 Uncharacterized gene A6 protein
VGA8_ALHV1 Uncharacterized gene A8 protein
VGA4_ALHV1 Uncharacterized gene A4 protein
VGA5_ALHV1 G-protein coupled receptor A5
VGA9_ALHV1 Putative apoptosis regulator A9
VP03_ALHV1 Probable tegument protein antigen 3
UL91_ALHV1 Uncharacterized gene 30 protein
UL95_ALHV1 Gene 34 protein
UNG_ALHV1 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG27_ALHV1 Uncharacterized gene 27 protein
VG73_ALHV1 Uncharacterized gene 73 protein
VG40_ALHV1 Uncharacterized gene 40 protein
TRM3_ALHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL96_ALHV1 Gene 35 protein
TRM2_ALHV1 Tripartite terminase subunit 2
VP75_ALHV1 Probable membrane antigen 75 (Tegument protein)
VG36_ALHV1 Putative tyrosine kinase 36 (EC 2.7.10.2)
VG10_ALHV1 Uncharacterized gene 10 protein
VGA10_ALHV1 Uncharacterized gene A10 protein
VGA1_ALHV1 Uncharacterized gene A1 protein
VGA7_ALHV1 Putative C-type lectin protein A7
VG52_ALHV1 Uncharacterized gene 52 protein
DNBI_ALHV1 Major DNA-binding protein
CVC2_ALHV1 Capsid vertex component 2
DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC1_ALHV1 Capsid vertex component 1
CEP2_ALHV1 Cytoplasmic envelopment protein 2
CEP3_ALHV1 Cytoplasmic envelopment protein 3
BRLF1_ALHV1 Putative transcription activator BRLF1 homolog
AN_ALHV1 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
IE63_ALHV1 Immediate-early phosphoprotein 57
GB_ALHV1 Envelope glycoprotein B (gB)
GL_ALHV1 Envelope glycoprotein L (gL)
HELI_ALHV1 DNA replication helicase (EC 3.6.4.-)
RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
SEMA_ALHV1 Semaphorin-like protein A3
SCP_ALHV1 Small capsomere-interacting protein
TEG7_ALHV1 Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
ITP_ALHV1 Inner tegument protein
GM_ALHV1 Envelope glycoprotein M (gM)
GN_ALHV1 Envelope glycoprotein N
KITH_ALHV1 Thymidine kinase (EC 2.7.1.21)
CEP1_ALHV1 Cytoplasmic envelopment protein 1
DPOL_ALHV1 DNA polymerase catalytic subunit (EC 2.7.7.7)
MCP_ALHV1 Major capsid protein (MCP)
GH_ALHV1 Envelope glycoprotein H (gH)
LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_ALHV1 Nuclear egress protein 1
NEC2_ALHV1 Nuclear egress protein 2
TRX2_ALHV1 Triplex capsid protein 2
UL24_ALHV1 Protein UL24 homolog
UL49_ALHV1 Uncharacterized gene 66 protein
UL79_ALHV1 Gene 18 protein
UL87_ALHV1 Uncharacterized gene 24 protein
PORTL_ALHV1 Portal protein
PRIM_ALHV1 DNA primase (EC 2.7.7.-)
TRX1_ALHV1 Triplex capsid protein 1
SCAF_ALHV1 Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR) [Cleaved into: Assemblin ...

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

KITH_AHV1W Thymidine kinase (EC 2.7.1.21)