Enveloped. extracellular baculovirus virions can be found in two forms: OV (occluded virus) and BV (budded virus). The nucleocapsid is about 21 nm x 260 nm.


Circular dsDNA, 80-180 kb in length, encoding for 100 to 180 proteins.




  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane.
  3. The DNA genome is released into the host nucleus.
  4. Immediate early phase: host RNA polymerase transcribes viral genes involved in the regulation of the replication cascade, prevention of host responses and viral DNA synthesis.
  5. Late phase: The virally encoded RNA polymerase expresses late genes.
  6. Replication of the genome by rolling circle in nuclear viral factories.
  7. Nucleocapsids are formed which can either bud out through the cellular membrane and disseminate the infection or be occluded for horizontal transmission.
  8. Occlusion phase: the virus becomes occluded in the protein polyhedrin and the polyhedral envelope (calyx) is produced. Lysis of the cell releases the occluded virus.

Matching UniProtKB/Swiss-Prot entries

22 entries grouped by strain (browse by keywords)

4 entries

Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) reference strain

OE56_GVCPM Occlusion-derived virus envelope protein E56 (ODV-E56) (ODVP-6E)
IAP_GVCPM Apoptosis inhibitor IAP
GRAN_GVCPM Granulin (Matrix protein)
CATV_GVCPM Viral cathepsin (V-cath) (EC (Cysteine proteinase) (CP)

6 entries

Cryptophlebia leucotreta granulosis virus (ClGV) (Cryptophlebia leucotreta granulovirus)

LEF5_GVCL Late expression factor 5 homolog
Y098_GVCL Uncharacterized 41.0 kDa protein in P143-LEF5 intergenic region
YP73_GVCL Uncharacterized protein in P7.3 3'region
Y096_GVCL Uncharacterized 18.6 kDa protein in P143-LEF5 intergenic region
BVCP_GVCL DNA-binding protein (Arginine-rich protein 7.3 kDa) (Basic viral core protein) (Nucleocapsid ...
GRAN_GVCL Granulin (Matrix protein)

2 entries

Trichoplusia ni granulosis virus (TnGV) (Trichoplusia ni granulovirus)

VEF_GVTN Viral-enhancing factor (Enhancin) (VEF) (104 kDa glycoprotein) (Synergistic factor)
GRAN_GVTN Granulin (Matrix protein)

2 entries

Xestia c-nigrum granulosis virus (XnGV) (Xestia c-nigrum granulovirus)

CATV_GVXN Viral cathepsin (V-cath) (EC (Cysteine proteinase) (CP)
GRAN_GVXN Granulin (Matrix protein)

1 entry

Adoxophyes orana granulovirus (AoGV)

GRAN_GVAO Granulin (Matrix protein)

1 entry

Agrotis segetum granulosis virus (AsGV) (Agrotis segetum granulovirus)

GRAN_GVAS Granulin (Matrix protein)

1 entry

Choristoneura fumiferana granulovirus (CfGV)

GRAN_GVCF Granulin (Matrix protein)

1 entry

Harrisina brillians granulovirus (HbGV)

GRAN_GVHB Granulin (Matrix protein)

1 entry

Heliothis armigera granulosis virus (HaGV) (Heliothis armigera granulovirus)

VEF_GVHA Viral-enhancing factor (Enhancin) (VEF) (104 kDa glycoprotein) (Synergistic factor)

1 entry

Lacanobia oleracea granulosis virus (LoGV) (Lacanobia oleracea granulovirus)

UDPE_GVLO Ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-)

1 entry

Pieris brassicae granulosis virus (PbGV) (Pieris brassicae granulovirus)

GRAN_GVPB Granulin (Matrix protein)

1 entry

Pseudalatia unipuncta granulosis virus (PuGV) (Pseudalatia unipuncta granulovirus)

VEF_GVPU Viral-enhancing factor (Enhancin) (VEF) (104 kDa glycoprotein) (Synergistic factor)