Tymoviridae

VIRION

Non-enveloped, isometric capsid with T=3 icosahedral symmetry, about 30 nm in diameter.

GENOME

Monopartite, linear, C-rich, ssRNA(+) genome of 6-7.5 kb. The 3'-terminus may have a tRNA-like structure or a polyA tract, depending upon the virus.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The virion RNA is infectious and serves as both the genome and viral messenger RNA. The ORF1 encodes a polyprotein whichis expressed by leaky scanning. The capsid protein is translated from a subgenomic RNA.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the protein necessary for RNA synthesis (replication and transcription).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes an internal subgenomic promoter on the negative-sense RNA to transcribe the 3’co-terminal subgenomic RNA that will generate the capsid protein.
  7. Assembly of new virus particles.

Host-virus interaction

Modulation of host ubiquitin pathway by virus

Turnip yellow mosaic virus 98K replication protein counteracts degradation of its RNA-dependent RNA polymerase (RdRp) by the host ubiquitin-proteasome system. The viral 98K replication protein mediates deubiquitylation of RdRp leading to its stabilization .

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

4 entries

Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

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RDRP_GFKVM RNA replication protein [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); Helicase (EC ...
ORF3_GFKVM Uncharacterized protein ORF3
ORF4_GFKVM Uncharacterized protein ORF4
CAPSD_GFKVM Capsid protein (CP) (Coat protein)

3 entries

Turnip yellow mosaic virus reference strain

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POLR_TYMV RNA replicase polyprotein (206 kDa polyprotein) [Cleaved into: Methyltransferase/Protease (EC ...
P69_TYMV 69 kDa protein (p69)
COAT_TYMV Coat protein (Virion protein)

2 entries

Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain

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POLG_MRFVC Genome polyprotein [Cleaved into: RNA replication protein; Capsid protein CP1 (CP1) (Coat protein)] ...
MOVP_MRFVC Putative movement protein

3 entries

Eggplant mosaic virus

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POLR_EPMV RNA replicase polyprotein (EC 2.7.7.48)
P69_EPMV 70 kDa protein
COAT_EPMV Coat protein (Virion protein)

3 entries

Erysimum latent virus (ELV)

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POLR_ELV RNA replicase polyprotein (EC 2.7.7.48)
COAT_ELV Coat protein (Virion protein)
Y48K_ELV Uncharacterized 48 kDa protein

3 entries

Ononis yellow mosaic virus

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POLR_OYMV RNA replicase polyprotein (EC 2.7.7.48)
P69_OYMV 66 kDa protein
COAT_OYMV Coat protein (Virion protein)

3 entries

Turnip yellow mosaic virus (isolate Australia)

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POLR_TYMVA RNA replicase polyprotein (EC 2.7.7.48)
P69_TYMVA 69 kDa protein (p69)
COAT_TYMVA Coat protein (Virion protein)

2 entries

Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)

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POLR_KYMVJ RNA replicase polyprotein (EC 2.7.7.48)
COAT_KYMVJ Coat protein (Virion protein)

2 entries

Turnip yellow mosaic virus (isolate TYMC)

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POLR_TYMVC RNA replicase polyprotein (EC 2.7.7.48)
P69_TYMVC 69 kDa protein (p69)

1 entry

Belladonna mottle virus (BMDV)

COAT_BMDV Coat protein (Virion protein)

1 entry

Cacao yellow mosaic virus

COAT_CAYMV Coat protein (Virion protein)

1 entry

Physalis mottle virus (PhMV) (Belladonna mottle virus-Iowa)

COAT_PHMV Coat protein (Virion protein)