Syncytium formation induced by viral infection

Syncytia result from the fusion of an infected cell with neighboring cells, leading to the formation of multinucleated, enlarged cells. This process is triggered by the surface expression of viral fusion proteins that are fusogenic directly at the host cell membrane.
Syncytia can only arise with viruses that are able to fuse directly at the cell surface without requiring endocytosis.

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Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Links Uniprot Keyword: KW-1180
GO ontology:GO:0060141
Virus Herpesviridae
Paramyxoviridae
Poxviridae
Reoviridae
Retroviridae

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

21 entries grouped by protein

8 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
FUS_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain

pdb 2MDP; 3IXT; 3KPE; 3O41; 3O45; 3RKI; 3RRR; 3RRT; 4CCF; 4JHW; 4MMQ; 4MMR; 4MMS; 4MMT; 4MMU; 4MMV; 4ZYP; 5C69; 5C6B; 5EA3; 5EA4; 5EA5; 5EA6; 5EA7; 5EA8; 5J3D; 5K6B; 5K6C; 5K6F; 5K6G; 5K6H; 5K6I; 5KWW; 5TOJ; 5TOK; 5TPN; 5U68; 5UDC; 5W23; 6APB; 6APD; 6CXC; 6DC3; 6DC5; 6EAD; 6EAE; 6EAF; 6EAG; 6EAH; 6EAI; 6EAJ; 6EAK; 6EAL; 6EAM; 6EAN; 6NTX; 6OE4; 6OE5; 6OJ7; 6OUS; 6VKC; 6VKD; 6VKE; 6W52; 7LUE; 7LVW; 7MMN; 7MPG

FUS_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_BRSVC
Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

pdb 5TDL

FUS_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
FUS_HRSV1
Human respiratory syncytial virus B (strain 18537)

pdb 6Q0S

FUS_HRSVL
Human respiratory syncytial virus A (strain Long)
FUS_HRSVR
Human respiratory syncytial virus A (strain RSS-2)

pdb 1G2C

13 entries

Envelope glycoprotein K (Syncytial protein)

Select_allDeselect_all
GK_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
GK_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

Envelope glycoprotein K

GK_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GK_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GK_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
GK_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
GK_EHV1K
Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)
GK_HHV19
Human herpesvirus 1 (strain R19) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1M
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1R
Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
GK_SUHVK
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
GK_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)