Paramyxoviridae (taxid:11158)
VIRION

Enveloped, spherical. Diameter of about 150 nm.
GENOME
Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins. Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase, (Neuraminidase)
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. Most express a C protein by leaky scanning and V/W proteins by mRNA editing.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
- Neuraminidase [HN]
REPLICATION
CYTOPLASMIC
- Virus attaches to host cell surface receptors through HN, H or G glycoproteins.
- Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
- sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthesized antigenomes and genomes.
- The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
Host-virus interaction
Inhibition of host Interferon induction
The V protein plays a role in inhibition of MDA-5 antiviral signaling
The Nipah P,V and W proteins play a role in inhibition of STAT1 antiviral signaling
The Sendai C protein plays a role in inhibition of STAT1 antiviral signaling
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)340 entries grouped by protein
25 entries
Protein C
50 entries
Fusion glycoprotein F0
2 entries
Glycoprotein G
14 entries
Hemagglutinin glycoprotein
43 entries
Hemagglutinin-neuraminidase (EC 3.2.1.18)
2 entries
I
22 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
38 entries
Matrix protein
44 entries
Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
44 entries
Phosphoprotein (Protein P)
16 entries
Small hydrophobic protein
31 entries
Non-structural protein V
8 entries
Protein W
1 entry
Putative uncharacterized 7 kDa protein
Achimota virus 1 taxid:1261100
Achimota virus 2 taxid:1261101
Caprine parainfluenza virus 3 taxid:1529392
Cedar virus taxid:1221391
Ghana virus taxid:2847089
Hendra virus (isolate Horse/Autralia/Hendra/1994) taxid:928303
Henipavirus hendraense taxid:3052223
Human parainfluenza virus 1 strain Washington/1964 taxid:188538
Human respirovirus 1 taxid:12730
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43015 |
Hemagglutinin | ma-jd-viral-13174 |
J virus taxid:322067
Measles morbillivirus taxid:11234
Measles virus (strain Edmonston B) taxid:70146
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43011 |
Measles virus (strain Edmonston) taxid:11235
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43011 |