Aquareovirus (taxid:10979)



Non enveloped, icosahedral virion with a double capsid structure, about 75 nm in diameter. Pentameric turrets sit on the outside of the innermost capsid. The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.



Segmented linear dsRNA genome. Contains 11 segments coding for 12 proteins. Segments size range from 0.8 to 4.0 kb. Genome total size range from 18.2 to 30.5 kb.


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response of dsRNA. Viral polymerase synthesizes mRNA from each dsRNA segment which are translocated to the cell cytoplasm where they are translated.




  1. Attachment to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to website)

27 entries grouped by strain

12 entries

Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

VP4_AQRVC Outer capsid protein VP4
CAPSD_AQRVC Major inner capsid protein VP3 (EC (ATP-dependent DNA helicase VP3)
VNS2_AQRVC Non-structural protein 2 (NS2)
VP7_AQRVC Outer capsid protein VP7
VP6_AQRVC Clamp protein VP6
VP5_AQRVC Microtubule-associated protein VP5
VNS1_AQRVC Non-structural protein 1 (NS1)
RDRP_AQRVC RNA-directed RNA polymerase VP2 (EC
VP1_AQRVC Outer capsid protein VP1 [Includes: mRNA guanylyltransferase (EC; mRNA ...
VNS3_AQRVC Non-structural protein 3 (NS3)
VNS4_AQRVC Non-structural protein 4 (NS4)
VNS5_AQRVC Non-structural protein 5 (NS5)

12 entries

Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

CAPSD_AQRVG Major inner capsid protein VP3 (EC (ATP-dependent DNA helicase VP3)
VP4_AQRVG Outer capsid protein VP4
VP1_AQRVG Outer capsid protein VP1 [Includes: mRNA guanylyltransferase (EC; mRNA ...
RDRP_AQRVG RNA-directed RNA polymerase VP2 (EC
VNS1_AQRVG Non-structural protein 1 (NS1) (NS73)
VP5_AQRVG Microtubule-associated protein VP5
VNS5_AQRVG Non-structural protein 5 (NS5) (NS16)
VP6_AQRVG Clamp protein VP6
VNS2_AQRVG Non-structural protein 2 (NS2)
VP7_AQRVG Outer capsid protein VP7
VNS4_AQRVG Non-structural protein 4 (NS4) (NS31)
VNS3_AQRVG Non-structural 3 (NS3) (NS26)

3 entries

Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

CAPSD_AQRVA Major inner capsid protein VP3 (EC (ATP-dependent DNA helicase VP3)
RDRP_AQRVA RNA-directed RNA polymerase VP2 (EC
VP1_AQRVA Outer capsid protein VP1 [Includes: mRNA guanylyltransferase (EC; mRNA ...