Polerovirus (taxid:119164)

VIRION

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Non-enveloped, spherical virion about 23 nm in diameter with T=3 icosahedral symmetry composed of 180 CP proteins, with some percentage containing a readthrough domain (RTD) extension located on the particle's surface.
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GENOME

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Monopartite, linear, ssRNA(+) genome of 5.3-5.7 kb in size with a VPg bound at the 5' end. There is no poly(A) tail or tRNA-like structure at the 3' end.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The polymerase is expressed by a ribosomal frameshifting near the end of ORF1. Rap1 translation initiates about 1500 nt downstream of the 5' end of the gRNA by an unusual internal ribosome entry site (IRES).
The movement protein (MVP) and P3a are expressed by leaky scanning of the subgenomic mRNA. Suppression of termination of the CP stop codon produces CP-RTD (CP extended), the capsid subunit essential for aphid transmission.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA ORF1 and ORF2 are translated to produce the RdRp fusion protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the 3' coterminal sgRNAs. Traduction of these sgRNAs yields the capsid, CP-RTD and movement proteins.
  7. Virus assembly.
  8. Viral movement protein probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Polerovirus protein P0 acts as a suppressor of RNA silencing by targeting Argonaute 1 for degradation .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

29 entries grouped by strain

9 entries

Potato leafroll virus (strain Potato/Scotland/strain 1/1984) (PLrV) reference strain

Select_allDeselect_all
P1_PLRV1 Protein P1 (69.7 kDa protein) (Genome-linked protein precursor) (Protein ORF1) [Cleaved into: Serine ...
RDRP_PLRV1 Protein P1-P2 [Cleaved into: Serine protease (EC 3.4.21.-); RNA-directed RNA polymerase (EC ...
MVP_PLRV1 Movement protein P17 (MP) (17 kDa protein) (MP17)
MCAPS_PLRV1 Readthrough protein P3-RTD (P3-P5 readthrough protein) (P74) (Readthrough protein) (RT protein) ...
P3A_PLRV1 Movement protein P3a (Protein ORF3a)
P0_PLRV1 Suppressor of silencing P0 (28 kDa protein) (Protein ORF0)
CAPSD_PLRV1 Major capsid protein (Coat protein) (CP) (P3)
RAP1_PLRV1 Replication-associated protein (Rap1)
P6_PLRV1 Uncharacterized protein P6 (ORF6 protein)

7 entries

Turnip yellows virus (isolate FL-1) (TuYV) (BWYV-FL1) reference strain

Select_allDeselect_all
MCAPS_TYYVF Readthrough protein P3-RTD (P3-P5 readthrough protein) (P74) (Readthrough protein) (RT protein) ...
P1_TYYVF Protein P1 (66.2 kDa protein) (Genome-linked protein precursor) (Protein ORF1) [Cleaved into: Serine ...
RDRP_TYYVF Protein P1-P2 [Cleaved into: Serine protease (EC 3.4.21.-); RNA-directed RNA polymerase (EC ...
MVP_TYYVF Movement protein (MP) (20 kDa protein)
P3A_TYYVF P3a (Protein ORF3a)
P0_TYYVF Suppressor of silencing P0 (29 kDa protein) (Protein ORF0)
CAPSD_TYYVF Major capsid protein (Coat protein) (CP)

8 entries

Potato leafroll virus (strain Potato/Netherlands/Wageningen/1989) (PLrV)

Select_allDeselect_all
P1_PLRVW Protein P1 (69.7 kDa protein) (Genome-linked protein precursor) (Protein ORF1) [Cleaved into: Serine ...
RDRP_PLRVW Protein P1-P2 [Cleaved into: Serine protease (EC 3.4.21.-); RNA-directed RNA polymerase (EC ...
MCAPS_PLRVW Readthrough protein P3-RTD (P3-P5 readthrough protein) (P74) (Readthrough protein) (RT protein) ...
MVP_PLRVW Movement protein P17 (MP) (17 kDa protein) (MP17)
P0_PLRVW Suppressor of silencing P0 (28 kDa protein) (Protein ORF0)
CAPSD_PLRVW Major capsid protein (Coat protein) (CP) (P3)
P6_PLRVW Uncharacterized protein P6 (ORF6 protein)
RAP1_PLRVW Replication-associated protein (Rap1)

2 entries

Potato leafroll virus (PLrV)

Select_allDeselect_all
MVP_PLRV Movement protein P17 (MP) (17 kDa protein) (MP17)
CAPSD_PLRV Major capsid protein (Coat protein) (CP) (P3)

2 entries

Potato leafroll virus (strain Potato/Canada/Rowhani/1979) (PLrV)

Select_allDeselect_all
MVP_PLRVR Movement protein P17 (MP) (17 kDa protein) (MP17)
CAPSD_PLRVR Major capsid protein (Coat protein) (CP) (P3)

1 entry

Beet western yellows virus (isolate GB1) (BWYV)

MVP_BWYVG Movement protein (MP) (20 kDa protein)