Betanodavirus (taxid:143919)



Non enveloped virion, about 30 nm in diameter with a T=3 icosahedral symmetry (180 protein subunits).



Segmented, bipartite linear, ssRNA(+) genome composed of RNA1=3.1 kb and RNA2=1.4 kb. Each genome segment 5' end is capped. The 3'end has no poly (A) tract.


The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA1 encodes directly the RNA-dependent RNA polymerase (protein A), and RNA2, the capsid protein. A subgenomic RNA (sgRNA3), 3' co-linear to RNA1 is also produced and encode proteins B1 and B2.




  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA-1 is translated to produce the RdRp protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA-3.
  7. Translation of RNA-2 encoding capsid protein alpha.
  8. Virus assembly in the cytoplasm around genomic RNA1 and RNA2.
  9. Assembled capsid protein alpha is cleaved into capsid protein beta and gamma.
  10. Release of infectious particles (lysis?).

Host-virus interaction

Suppression of RNA silencing

Striped jack nervous necrosis virus B protein acts as a suppressor of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

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5 entries grouped by strain

3 entries

Striped jack nervous necrosis virus (SjNNV) reference strain

CAPSD_SJNNV Capsid protein alpha
RDRP_SJNNV RNA-directed RNA polymerase (RdRp) (EC (RNA replicase) (Protein A)
B_SJNNV Protein B

1 entry

Atlantic halibut nervous necrosis virus (AhNNV)

RDRP_AHNNV RNA-directed RNA polymerase (RdRp) (EC (RNA replicase) (Protein A)

1 entry

Greasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)

RDRP_GGNNV RNA-directed RNA polymerase (RdRp) (EC (RNA replicase) (Protein A)