VIRION
Non-enveloped virion, icosahedral virus.
GENOME
Circular ssDNA genome of about 5-6 kb that is partially double stranded on about 800bp. Encodes for 3 proteins.
GENE EXPRESSION
ENZYMES
REPLICATION
NUCLEUS
- Virus penetrates into the host cell.
- Uncoating, the viral ssDNA genome penetrates into the nucleus.
- Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
- Viral mRNAs are translated to produce viral proteins.
- Replication may be mediated by a Rep protein, and would occur by rolling circle producing ssDNA genomes.
- These newly synthesized ssDNA can either
a) be converted to dsDNA and serve as a template for transcription/replication
b) be encapsidated by capsid protein and form virions released by cell lysis.