Chipapillomavirus (taxid:934800)



Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the capsid, which is composed of 72 pentamers arranged on a T = 7 lattice.


Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumors.


Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins.
b) Late Proteins: the structural proteins.



Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Canis familiaris papillomavirus 10 taxid:1087109

Protein ModelArchive
E4 ma-jd-viral-48089
Major capsid protein L1 ma-jd-viral-67214
Minor capsid protein L2 ma-jd-viral-44917
Protein E6 ma-jd-viral-00946
Protein E7 ma-jd-viral-13710
Regulatory protein E2 ma-jd-viral-61181
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21279

Canis familiaris papillomavirus 16 taxid:1619253

Protein ModelArchive
E4 ma-jd-viral-48090
E5 ma-jd-viral-44116
Major capsid protein L1 ma-jd-viral-67321
Minor capsid protein L2 ma-jd-viral-44890
Protein E6 ma-jd-viral-00933
Protein E7 ma-jd-viral-13689
Regulatory protein E2 ma-jd-viral-61152
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21261

Canis familiaris papillomavirus 3 taxid:360397

Protein ModelArchive
Major capsid protein L1 ma-jd-viral-67228
Minor capsid protein L2 ma-jd-viral-44993
Protein E6 ma-jd-viral-00877
Protein E7 ma-jd-viral-13693
Regulatory protein E2 ma-jd-viral-61180
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21277

Canis familiaris papillomavirus 4 taxid:464980

Protein ModelArchive
Major capsid protein L1 ma-jd-viral-67346
Minor capsid protein L2 ma-jd-viral-44973
Protein E6 ma-jd-viral-00881
Protein E7 ma-jd-viral-13737
Regulatory protein E2 ma-jd-viral-61164
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21315

Canis familiaris papillomavirus 8 taxid:1081055

Protein ModelArchive
E4 ma-jd-viral-48091
Major capsid protein L1 ma-jd-viral-67306
Minor capsid protein L2 ma-jd-viral-44959
Protein E6 ma-jd-viral-00908
Protein E7 ma-jd-viral-13732
Regulatory protein E2 ma-jd-viral-61161
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21278

Canis familiaris papillomavirus 9 taxid:1087108

Protein ModelArchive
E4 ma-jd-viral-48092
Major capsid protein L1 ma-jd-viral-67323
Minor capsid protein L2 ma-jd-viral-44933
Protein E6 ma-jd-viral-00967
Protein E7 ma-jd-viral-13711
Regulatory protein E2 ma-jd-viral-61135
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21289