Gammaretrovirus

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 8.3 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5’LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag, and gag-(pro)pol (suppression of termination of the gag termination codon). The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. Glyco-GAG is translated by noncanonical initiation of translation .

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

50 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 114 entries)

3 entries

Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Select_allDeselect_all
POL_MLVMS Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GAG_MLVMS Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_MLVMS Envelope glycoprotein (Pr80env) (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein ...

3 entries

Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

Select_allDeselect_all
POL_XMRV6 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_XMRV6 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV6 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

4 entries

AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)

Select_allDeselect_all
ENV_MLVAV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
POL_MLVAV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_MLVAV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GGAG_MLVAV Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)

4 entries

Friend murine leukemia virus (isolate 57) (FrMLV)

Select_allDeselect_all
POL_MLVF5 Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GGAG_MLVF5 Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_MLVF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
ENV_MLVF5 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

4 entries

Friend murine leukemia virus (isolate FB29) (FrMLV)

Select_allDeselect_all
POL_MLVFF Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GGAG_MLVFF Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_MLVFF Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
ENV_MLVFF Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

4 entries

Friend murine leukemia virus (isolate PVC-211) (FrMLV)

Select_allDeselect_all
ENV_MLVFP Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
POL_MLVFP Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GGAG_MLVFP Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_MLVFP Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

3 entries

Baboon endogenous virus (strain M7)

Select_allDeselect_all
POL_BAEVM Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_BAEVM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_BAEVM Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

3 entries

Gibbon ape leukemia virus (GALV)

Select_allDeselect_all
POL_GALV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_GALV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_GALV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

3 entries

Koala retrovirus (KoRV)

Select_allDeselect_all
POL_KORV Gag-Pol polyprotein (Pr125Pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein ...
ENV_KORV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_KORV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Radiation murine leukemia virus

Select_allDeselect_all
ENV_MLVRD Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...
POL_MLVRD Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_MLVRD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

Select_allDeselect_all
TSIS_WMSV PDGF-related-transforming protein sis (p28sis)
POL_WMSV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_WMSV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP35) (XMRV)

Select_allDeselect_all
ENV_XMRV3 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
POL_XMRV3 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GAG_XMRV3 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP42) (XMRV)

Select_allDeselect_all
POL_XMRV4 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_XMRV4 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV4 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

Select_allDeselect_all
FOSX_MSVFR Transforming protein v-Fos/v-Fox
GAG_MSVFR Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Feline leukemia virus

Select_allDeselect_all
GAG_FLV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_FLV Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...

1 entry

Harvey murine sarcoma virus

RASH_MSVHA Transforming protein p29 [Cleaved into: Transforming protein p21]

1 entry

Moloney murine sarcoma virus (MoMSV)

GAG_MSVMO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Murine leukemia virus (strain BM5 eco)

POL_MLVBM Gag-pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...