Pipapillomavirus (taxid:334211)



Non-enveloped. Small, icosahedral, about 52-55 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.



Circular dsDNA probably associated with cellular histones. The E2 and L2 ORFs are partially overlapping.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.


Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing:
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.


NUCLEAR Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

1 entry grouped by strain

1 entry

Micromys minutus papillomavirus (MmPV) (Old world harvest mouse papillomavirus)

VE6_MMPV Protein E6
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Apodemus sylvaticus papillomavirus 1 taxid:1036963

Protein ModelArchive
E4 ma-jd-viral-46637
Major capsid protein L1 ma-jd-viral-67281
Minor capsid protein L2 ma-jd-viral-44902
Protein E6 ma-jd-viral-00869
Protein E7 ma-jd-viral-13685
Regulatory protein E2 ma-jd-viral-61085
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21236

Mesocricetus auratus papillomavirus 1 taxid:1408129

Protein ModelArchive
E4 protein ma-jd-viral-30328
Major capsid protein L1 ma-jd-viral-67280
Minor capsid protein L2 ma-jd-viral-44910
Protein E6 ma-jd-viral-00849
Protein E7 ma-jd-viral-13641
Regulatory protein E2 ma-jd-viral-61041
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21232

Micromys minutus papillomavirus taxid:10568

Protein ModelArchive
E4 ma-jd-viral-46639
Major capsid protein L1 ma-jd-viral-67248
Minor capsid protein L2 ma-jd-viral-44883
Protein E6 ma-jd-viral-00850
Protein E6 ma-jd-viral-00850
Protein E7 ma-jd-viral-13705
Regulatory protein E2 ma-jd-viral-61080
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21329

Mus musculus papillomavirus type 1 taxid:763552

Protein ModelArchive
E4 ma-jd-viral-46638
Major capsid protein L1 ma-jd-viral-67315
Minor capsid protein L2 ma-jd-viral-44944
Protein E6 ma-jd-viral-00861
Protein E7 ma-jd-viral-13691
Regulatory protein E2 ma-jd-viral-61101
Replication protein E1 (EC (ATP-dependent helicase E1) ma-jd-viral-21270