Bafinivirus (taxid:694018)



Enveloped, spherical, about 120 to 140nm in diameter. The tubular nucleocapsid is bend into an open torus hence the name "torovirus".



Monopartite, linear ssRNA(+) genome of 28kb in size. Capped, and polyadenylated.


Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting proteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.




  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by E2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Matching UniProtKB/Swiss-Prot entries

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5 entries grouped by strain

5 entries

White bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV) reference strain

R1A_WBV24 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: N7-guanine methyltransferase (EC ...
R1AB_WBV24 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: N7-guanine methyltransferase ...
VME1_WBV24 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_WBV24 Spike glycoprotein (S glycoprotein)
NCAP_WBV24 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)