Enveloped, bullet shaped. 180 nm long and 75 nm wide.



Negative-stranded RNA linear genome, about 11kb in size. Encodes for six proteins.


The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.



  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host apoptosis

The NV protein of VHSV has an antiapoptotic function at the early stage of the virus infection

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by strain (browse by keywords)

6 entries

Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV) reference strain

PHOSP_HIRRV Phosphoprotein (Protein P) (Protein M1)
GLYCO_HIRRV Glycoprotein
NCAP_HIRRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_HIRRV Matrix protein
L_HIRRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NV_HIRRV Non-virion protein

6 entries

Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain

PHOSP_IHNVW Phosphoprotein (Protein P) (Protein M1)
NV_IHNVW Non-virion protein
GLYCO_IHNVW Glycoprotein (Spike glycoprotein)
MATRX_IHNVW Matrix protein (Protein M2)
NCAP_IHNVW Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_IHNVW RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

6 entries

Snakehead rhabdovirus (SHRV) reference strain

PHOSP_SHRV Phosphoprotein (Protein P) (Protein M1)
NV_SHRV Non-virion protein
GLYCO_SHRV Glycoprotein
NCAP_SHRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_SHRV Matrix protein
L_SHRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

6 entries

Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

L_IHNVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_IHNVO Matrix protein (Protein M2)
PHOSP_IHNVO Phosphoprotein (Protein P) (Protein M1)
GLYCO_IHNVO Glycoprotein (Spike glycoprotein)
NCAP_IHNVO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVO Non-virion protein

3 entries

Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)

NV_IHNVR Non-virion protein
NCAP_IHNVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_IHNVR Glycoprotein (Spike glycoprotein)

2 entries

Viral hemorrhagic septicemia virus (strain 07-71) (VHSV)

GLYCO_VHSV0 Spike glycoprotein
NCAP_VHSV0 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Viral hemorrhagic septicemia virus (strain Makah) (VHSV)

NCAP_VHSVM Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)