Alphatorquevirus

VIRION

Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm..

GENOME

Circular ssDNA genome (-) of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a “Rep-like” protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

5 entries

Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

Select_allDeselect_all
CAPSD_TTVV3 Capsid protein
ORF24_TTVV3 ORF2/4 protein
ORF12_TTVV3 ORF1/2 protein
ORF11_TTVV3 ORF1/1 protein
ORF2_TTVV3 ORF2 protein

3 entries

Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV6 Capsid protein
ORF24_TTVV6 Uncharacterized ORF2/4 protein
ORF23_TTVV6 Probable protein VP2 (ORF2/3 protein)

3 entries

Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV4 Capsid protein
ORF24_TTVV4 Uncharacterized ORF2/4 protein
ORF23_TTVV4 Probable protein VP2 (ORF2/3 protein)

3 entries

Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV9 Capsid protein
YORF3_TTVV9 Uncharacterized ORF3 protein
YORF2_TTVV9 Uncharacterized ORF2 protein

2 entries

Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

Select_allDeselect_all
CAPSD_TTVV8 Capsid protein
ORF2_TTVV8 Uncharacterized ORF2 protein

2 entries

Torque teno virus 1 (isolate TA278) reference strain

Select_allDeselect_all
ORF2_TTVA1 Uncharacterized ORF2 protein
CAPSD_TTVA1 Capsid protein