Alphatorquevirus (taxid:687331)



Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm..



Circular ssDNA genome (-) of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.


The proteins are expressed by alternative splicing of pre-mRNA.



  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a "Rep-like" protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to website)

18 entries grouped by strain

5 entries

Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

CAPSD_TTVV3 Capsid protein
ORF24_TTVV3 ORF2/4 protein
ORF2_TTVV3 ORF2 protein
ORF12_TTVV3 ORF1/2 protein
ORF11_TTVV3 ORF1/1 protein

3 entries

Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

CAPSD_TTVV6 Capsid protein
ORF23_TTVV6 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV6 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain

CAPSD_TTVV4 Capsid protein
ORF23_TTVV4 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV4 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

YORF3_TTVV9 Uncharacterized ORF3 protein
CAPSD_TTVV9 Capsid protein
YORF2_TTVV9 Uncharacterized ORF2 protein

2 entries

Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

CAPSD_TTVV8 Capsid protein
ORF2_TTVV8 Uncharacterized ORF2 protein

2 entries

Torque teno virus 1 (isolate TA278) reference strain

CAPSD_TTVA1 Capsid protein
ORF2_TTVA1 Uncharacterized ORF2 protein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Simian torque teno virus 30 taxid:1619218

Protein ModelArchive
Capsid protein ma-jd-viral-04604
ORF2 ma-jd-viral-32711
ORF3 ma-jd-viral-55086

Simian torque teno virus 31 taxid:1619219

Protein ModelArchive
Capsid protein ma-jd-viral-04569
ORF2 ma-jd-viral-34684
ORF3 ma-jd-viral-30248
ORF4 ma-jd-viral-61743

Simian torque teno virus 32 taxid:1619220

Protein ModelArchive
Capsid protein ma-jd-viral-04575
ORF2 ma-jd-viral-34690
ORF3 ma-jd-viral-63052
ORF4 ma-jd-viral-61745

Simian torque teno virus 33 taxid:1629656

Protein ModelArchive
Capsid protein ma-jd-viral-04574
ORF2 ma-jd-viral-34686
ORF3 ma-jd-viral-53506
ORF4 ma-jd-viral-61744

Simian torque teno virus 34 taxid:1629657

Protein ModelArchive
Capsid protein ma-jd-viral-04587
ORF2 ma-jd-viral-64873
ORF3 ma-jd-viral-62659
ORF4 ma-jd-viral-46794

Torque teno virus 14 taxid:687353

Protein ModelArchive
Capsid protein ma-jd-viral-04603
Capsid protein ma-jd-viral-34685

Torque teno virus 2 taxid:687341

Protein ModelArchive
Capsid protein ma-jd-viral-04577
ORF2, ORF1 genes, isolate: s-TTV CH71 ma-jd-viral-34687