Gammapolyomavirus (taxid:1891716)



Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.



Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 9 proteins.


Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). Proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.



  1. Attachement of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to website)

6 entries grouped by strain

6 entries

Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain

VP2_BFPYV Minor capsid protein VP2 (Minor structural protein VP2)
VP1_BFPYV Major capsid protein VP1 (Major structural protein VP1)
LT_BFPYV Large T antigen (LT) (LT-AG) (EC 3.6.4.-)
AGNO2_BFPYV Avian agnoprotein 2b (Agno-2b)
ST_BFPYV Small t antigen (ST) (ST-AG)
AGNO1_BFPYV Avian agnoprotein 1a (Agno-1a)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Adelie penguin polyomavirus taxid:1590650

Protein ModelArchive
Large T antigen ma-jd-viral-21151
Minor capsid protein ma-jd-viral-31174
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29766
Small T antigen ma-jd-viral-16533
VP1 ma-jd-viral-14763

Butcherbird polyomavirus taxid:1394033

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14719
Large T antigen ma-jd-viral-21145
Minor capsid protein ma-jd-viral-31175
Minor capsid protein ma-jd-viral-29835
Small T antigen ma-jd-viral-16536
VP4 ma-jd-viral-33992

Canary polyomavirus taxid:881945

Protein ModelArchive
Large T antigen ma-jd-viral-21149
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-31153
Minor capsid protein VP2 (Minor structural protein VP2) ma-jd-viral-29759
Small t antigen ma-jd-viral-16535
Virus protein 1 ma-jd-viral-14744

Gammapolyomavirus corvi taxid:1891748

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14804
Large T antigen ma-jd-viral-21171
Minor capsid protein ma-jd-viral-29794
Minor capsid protein ma-jd-viral-29814
ORF-X ma-jd-viral-33993
Small t antigen ma-jd-viral-16532

Gammapolyomavirus pypyrrhula taxid:1891751

Protein ModelArchive
Capsid protein VP1 ma-jd-viral-14792
Large T antigen ma-jd-viral-21130
Minor capsid protein ma-jd-viral-31179
Minor capsid protein ma-jd-viral-29842
Putative ORF-X ma-jd-viral-64734
Putative small T antigen ma-jd-viral-16530