Inhibition of host tapasin by virus (kw:KW-1108)
Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on host cell surface. Its helps the MHC class I molecules to remain in a peptide receptive state, avoiding irresversible denaturation.
HCMV encodes a protein termed US3 that directly binds and inhibits Tapasin. US3 is also a transmembrane protein and the interaction with host tapasin occurs through their endoplasmic reticulum domain. The E3-19K protein from adenovirus also inhibit the pathway, by preventing association of Tapasin with TAP.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)7 entries grouped by strain
1 entry
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
1 entry
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain
1 entry
Human adenovirus B serotype 11 (strain BC34) (HAdV-11) (Human adenovirus 11A (strain BC34))
1 entry
Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
1 entry
Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3)
1 entry
Human adenovirus B serotype 35 (HAdV-35) (Human adenovirus 35)
1 entry