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Inhibition of host MHC class II molecule presentation by virus (kw:KW-1116)

MHC (major histocompatibility complex) Class II molecules are found only on a few specialized cells termed professional antigen-presenting cells (APCs). This group includes macrophages, dendritic cells and B cells.

nef US2

Several viruses interfere with MHC class II peptide presentation to avoid recognition and increase virus survival. They can either "intercept" the loaded MHC class II molecules and retain them in the endoplasmic reticulum or target them to degradation. For instance, cytomegalovirus US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. HIV-1 Nef is able to disrupt MHC class II-mediated antigen presentation by a dual strategy that comprises a reduction in cell surface levels of peptide-loaded mature MHC class II molecules and a up-regulation of immature MHC class II molecules. Vaccinia virus A35 protein localizes to endosomes and reduces the amount of a model antigenic peptide displayed in the cleft of MHC class II.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
MHC escape Inhibition of proteasome processing
Inhibition of host MHC class I
Inhibition of host MHC class II
Inhibition of host TAP
Inhibition of host tapasin
Links Uniprot Keyword: KW-1116
GO ontology: GO:0039505
Virus -Human cytomegalovirus (HHV-5)
(Herpesviridae ,Cytomegalovirus)
-HIV
(Retroviridae ,Lentivirus)
-Vacinia virus
(Poxviridae ,Orthopoxvirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

49 entries grouped by strain

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

VIRF3_HHV8P Viral IRF3-like protein (VIRF-3)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

NEF_HV1MA Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3W0W; 3WL9

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1) reference strain

NEF_HV1U4 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

NEF_HV1A2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RBB; 3REA; 3REB; 4ORZ; 4U1K; 4U1L; 4U1M; 4U1N; 4U5W; 5XOV; 6B72; 7D7S; 8F2P

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

NEF_HV1BR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1AVV; 1AVZ; 1EFN; 4D8D; 6URI

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

NEF_HV1H2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RL2; 4NEE; 4WU5; 4WU7; 5HGA; 5HGB; 5HGD; 5HGH; 7K80; 7K81; 7YG3; 8GVB; 8GVG; 8GVI; 9BL9; 9BLA

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

NEF_HV1MN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain

NEF_HV1RH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain

NEF_HV1B9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

NEF_HV192 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

NEF_HV1ET Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

NEF_HV1EL Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

NEF_HV193 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

NEF_HV1VI Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

NEF_HV190 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

NEF_HV1YF Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

NEF_HV1AN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3WLB

1 entry

Monkeypox virus reference strain

PG163_MONPV Protein OPG163

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVCZ Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVEK Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVMB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Vaccinia virus (strain Copenhagen) (VACV) reference strain

PG163_VACCC Protein OPG163

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

PG163_VACCW Protein OPG163

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)

NEF_HV1ZH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

NEF_HV1B1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1ZEC; 3TB8

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

NEF_HV1B8 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

NEF_HV1BN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

NEF_HV1H3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

NEF_HV1JR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

NEF_HV1LW Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 2NEF

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

NEF_HV1OY Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

NEF_HV112 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QA4; 1QA5; 1ZEC

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

NEF_HV1SC Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

NEF_HV1S1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

NEF_HV1S3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

NEF_HV1Y2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

NEF_HV1ND Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

NEF_HV1Z6 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QVO

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

NEF_HV1MP Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

NEF_HV1M2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

NEF_HV19N Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

NEF_HV1SE Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

NEF_HV1V9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

NEF_HV1S9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

NEF_HV1S2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

NEF_HV196 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

NEF_HV197 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

NEF_HV1YB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

NEF_HV1MV Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]