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Activation of host NF-kappa-B by virus (kw:KW-1074)

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In unstimulated cells, NF-kappa-B dimers are sequestered in the cytoplasm via physical association with NF-kappa-B inhibitory proteins, called I-kappa-Bs. Upon activation, NF-kappa-B separates from I-kappa-B and migrates to the nucleus to activate gene transcription.

TRAFs RIP RIP TRAFs TRADD TRADD TNF TNFR CD4 LCK PI3K AKT MEKK1 PKC IKKgamma IKKalpha IKKbeta IKb IKb NIK core VP4 BORF1

Multiple families of viruses have evolved sophisticated strategies to positively regulate nuclear factor-kappaB (NF-kappaB) signaling. Different viruses including HIV, herpesviruses, and HCV block apoptosis and prolong survival of the host cell in order to gain time for replication and increase viral progeny production. In addition, several oncogenic viruses are able to install a program of constitutive expression of NF-kB-dependent anti-apoptotic which results in cell transformation and uncontrolled proliferation.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
NF-kappaB modulation NF-kappaB activation
NF-kappaB inhibition
Links Uniprot Keyword: KW-1074
GO ontology: GO:0039652
Virus -HHV-1
(Herpesviridae, Simplexvirus)
-Epstein-Barr virus
(Herpesviridae, Lymphocryptorus)
-HTLV-1
(Retroviridae, Deltaretrovirus)
-HBV
(Hepadnaviridae, Orthohepadnavirus)
-Bovine foamy virus
(Retroviridae, Spumavirus)
-HRSV
(Paramyxoviridae, Pneumovirus)
-African swine fever virus
(Asfarviridae, Asfivirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

88 entries grouped by strain

2 entries

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Select_allDeselect_all
ICP27_HHV2H mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
US02_HHV2H Protein US2

1 entry

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

IAP_ASFB7 Inhibitor of apoptosis protein (IAP)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]

pdb 1CZY

1 entry

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

VCLAP_EHV2 CARD domain-containing protein E10

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C) reference strain

X_HBVC1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain

X_HBVCJ Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D) reference strain

X_HBVD7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

X_HBVD3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D) reference strain

X_HBVD4 Protein X (HBx) (Peptide X) (pX)

1 entry

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

TAX_HTL1C Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of ...

pdb 1AO7; 1BD2; 1HHK; 1IM3; 2AV1; 2AV7; 5IRO; 6UZ1; 7QRS; 7QRT; 7QS8

1 entry

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain

TAX_HTL1A Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of ...

pdb 7P73; 7PC3; 7PC4; 7PC9

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

UL144_HCMVM Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

ICP27_HHV11 mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

pdb 2KT5; 4YXP; 5BQK

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

VFLIP_HHV8P Viral FLICE protein (vFLIP)

pdb 5LDE; 7PDJ

1 entry

Human respiratory syncytial virus B (strain B1) reference strain

M21_HRSVB Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

1 entry

Woodchuck hepatitis B virus (isolate 8) (WHV) reference strain

X_WHV5 Protein X (HBx) (Peptide X) (pX)

1 entry

African swine fever virus (isolate Pig/Haiti/H811/1981) (ASFV)

IAP_ASFH8 Inhibitor of apoptosis protein (IAP) (IAP-like protein p27)

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

IAP_ASFK5 Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Pig/Portugal/Lis 60/1960) (ASFV)

IAP_ASFL6 IAP-like protein p27

1 entry

African swine fever virus (isolate Pig/Spain/E-75/1975) (ASFV)

IAP_ASFE7 IAP-like protein p27

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

IAP_ASFM2 Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

IAP_ASFP4 Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr5/1996) (ASFV)

IAP_ASFP5 Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Tick/South Africa/Wildebeeslaagte M1/1996) (ASFV)

IAP_ASFM1 Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Tick/Zimbabwe/Chiredzi Ch1/1983) (ASFV)

IAPL_ASFCH Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

IAP_ASFWA Inhibitor of apoptosis protein (IAP)

1 entry

African swine fever virus (strain E-70 MS16) (ASFV)

IAP_ASFE1 Inhibitor of apoptosis protein (IAP)

1 entry

Arctic squirrel hepatitis virus (ASHV)

X_ASHV Protein X (HBx) (Peptide X) (pX)

1 entry

Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)

X_HBVCP Protein X (HBx) (Peptide X) (pX)

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 8XH6; 8XH7

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 1ZMS

1 entry

Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)

X_HBVGB Protein X (HBx) (Peptide X) (pX)

1 entry

Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)

X_HBVGO Protein X (HBx) (Peptide X) (pX)

1 entry

Ground squirrel hepatitis virus (strain 27) (GSHV)

X_GSHV Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)

X_HBVA6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)

X_HBVA7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)

X_HBVA2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)

X_HBVA4 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)

X_HBVA3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)

X_HBVA9 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)

X_HBVA8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)

X_HBVB4 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

X_HBVB8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

X_HBVB7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)

X_HBVB1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)

X_HBVB2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)

X_HBVB5 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

X_HBVB3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

X_HBVB6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)

X_HBVC0 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)

X_HBVC5 Protein X (HBx) (Peptide X) (pX)

pdb 8WLS

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)

X_HBVC8 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)

X_HBVC3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)

X_HBVC2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

X_HBVC9 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)

X_HBVC7 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

X_HBVD2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)

X_HBVD5 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)

X_HBVD6 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)

X_HBVE3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)

X_HBVE2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)

X_HBVE4 Protein X (HBx) (Peptide X) (pX)

pdb 3I7H

1 entry

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)

X_HBVE1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)

X_HBVF2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)

X_HBVF4 Protein X (HBx) (Peptide X) (pX)

pdb 5FCG

1 entry

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)

X_HBVF1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)

X_HBVF6 Protein X (HBx) (Peptide X) (pX)

pdb 8GTX

1 entry

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)

X_HBVG3 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)

X_HBVH1 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)

X_HBVH2 Protein X (HBx) (Peptide X) (pX)

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)

X_HBVH3 Protein X (HBx) (Peptide X) (pX)

1 entry

Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

TAX_HTL1L Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

1 entry

Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1)

TAX_HTL1F Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

pdb 1BD2; 4E5X; 4FTV

1 entry

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

UL144_HCMVO Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)

1 entry

Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

ICP27_HHV1E mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

pdb 6FAD

1 entry

Human respiratory syncytial virus

M21_HRSV Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

pdb 5NKX

1 entry

Human respiratory syncytial virus A (strain A2)

M21_HRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

pdb 2L9J; 4C3B; 4C3D; 4C3E; 5NOH; 6G0Y; 6PZQ

1 entry

Orangutan hepatitis B virus (isolate Somad) (HBVoru)

X_HBVOR Protein X (HBx) (Peptide X) (pX)

1 entry

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

M21_ORSVW Protein M2-1 (Envelope-associated 22 kDa protein)

1 entry

Woodchuck hepatitis B virus (isolate 1) (WHV)

X_WHV1 Protein X (HBx) (Peptide X) (pX)

pdb 3I7K

1 entry

Woodchuck hepatitis B virus (isolate 2) (WHV)

X_WHV2 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate 59) (WHV)

X_WHV3 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate 7) (WHV)

X_WHV4 Protein X (HBx) (Peptide X) (pX)

1 entry

Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)

X_WHV6 Protein X (HBx) (Peptide X) (pX)

1 entry

Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

X_WMHBV Protein X (HBx) (Peptide X) (pX)