Activation of host NF-kappa-B by virus

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In unstimulated cells, NF-kappa-B dimers are sequestered in the cytoplasm via physical association with NF-kappa-B inhibitory proteins, called I-kappa-Bs. Upon activation, NF-kappa-B separates from I-kappa-B and migrates to the nucleus to activate gene transcription.

TRAFs RIP RIP TRAFs TRADD TRADD TNF TNFR CD4 LCK PI3K AKT MEKK1 PKC IKKgamma IKKalpha IKKbeta IKb IKb NIK core VP4 BORF1

Multiple families of viruses have evolved sophisticated strategies to positively regulate nuclear factor-kappaB (NF-kappaB) signaling. Different viruses including HIV, herpesviruses, and HCV block apoptosis and prolong survival of the host cell in order to gain time for replication and increase viral progeny production. In addition, several oncogenic viruses are able to install a program of constitutive expression of NF-kB-dependent anti-apoptotic which results in cell transformation and uncontrolled proliferation.

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by protein (browse by keywords)

All proteins are shown (view only 74 complete proteome entries)

5 entries

Inhibitor of apoptosis protein (IAP)

Select_allDeselect_all
IAP_ASFB7
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
IAP_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV) reference strain
IAP_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
IAP_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
IAP_ASFWA
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

3 entries

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

Select_allDeselect_all
ICP27_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

5 entries

Latent membrane protein 1 (LMP-1) (Protein p63)

Select_allDeselect_all
LMP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVC
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LMP1_EBVR
Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

5 entries

Matrix M2-1 (Envelope-associated 22 kDa protein)

Select_allDeselect_all
M21_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
M21_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain
M21_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
M21_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
M21_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

4 entries

Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)

Select_allDeselect_all
TAX_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain
TAX_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
TAX_HTL1F
Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

TAX_HTL1L
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

2 entries

Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)

Select_allDeselect_all
UL144_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL144_HCMVO
Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

1 entry

Protein US2

US02_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

1 entry

CARD domain-containing protein E10

VCLAP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Viral FLICE protein (vFLIP)

VFLIP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

55 entries

Protein X (HBx) (Peptide X) (pX)

Select_allDeselect_all
X_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
X_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B) reference strain
X_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B) reference strain
X_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B) reference strain
X_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
X_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D) reference strain
X_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
X_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV) reference strain
X_ASHV
Arctic squirrel hepatitis virus (ASHV)
X_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
X_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
X_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
X_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
X_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
X_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
X_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
X_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
X_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
X_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
X_HBVB5
Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)
X_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
X_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
X_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
X_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
X_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
X_HBVC5
Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
X_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
X_HBVC8
Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
X_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
X_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)
X_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
X_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
X_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
X_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
X_HBVE1
Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)
X_HBVE2
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)
X_HBVE3
Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)
X_HBVE4
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
X_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
X_HBVF2
Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)
X_HBVF4
Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)
X_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
X_HBVG3
Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)
X_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
X_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
X_HBVH1
Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)
X_HBVH2
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)
X_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
X_HBVOR
Orangutan hepatitis B virus (isolate Somad) (HBVoru)
X_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
X_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
X_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
X_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
X_WHV6
Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)
X_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)