Bevemovirus (taxid:2169648)

VIRION

Non-enveloped, flexuous, filamentous, of 760nm lengths x 12-15 nm in diameter with helical symmetry.

GENOME

Monopartite, linear, ssRNA(+) genome about 8.3kb in size. 3' terminus has a poly (A) tract. 5' terminus has a genome-linked protein (VPg).

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genomic RNA is translated into polyprotein subsequently processed into functional products.

Cleavage sites in the family Potyviridae

ENZYMES

• RNA-dependent RNA polymerase [Nlb-RdRp]
• VPG-type capping [VPg]
• Self cleavage N-ter polyprotein (Peptidase S30) [P1-pro]
• Self cleavage N-ter polyprotein (Peptidase C6) [HC-pro]
• Polyprotein protease (Peptidase C4) [Nla-pro]

REPLICATION

CYTOPLASMIC

1. Virus penetrates into the host cell.
2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
3. The viral RNA is translated to produce a polyprotein which is into the RdRp protein and structural proteins.
4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
6. Virus assembly in the cytoplasm.
7. Viral movement protein P3N-PIPO probably mediates virion cell-to-cell transfer.