Unfolded protein response (UPR)

Viruses can induce a lot of viral protein synthesis within the host cell. In Eukaryotes, protein over-production results in poor folded proteins in Endoplasmic reticulum in which chaperone are present in a limited ammount. This leads to the “Unfolded protein response” process which can result in either production of more chaperones, or lead the host cell to apoptosis.