Belongs to the DEDDh/DEEDh exonuclease family.
Coronavirus proofreading exoribonuclease (ExoN)
Enzyme reactions:
- Exonucleolytic cleavage EC=3.1.13.-;
Mechanism
| SARS-CoV-2 NSP14 |
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
Micka?l Bouvet, Isabelle Imbert, Lorenzo Subissi, Laure Gluais, Bruno Canard, Etienne Decroly
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9372-7
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN
Nicholas H Moeller, Ke Shi, ?zlem Demir, Christopher Belica, Surajit Banerjee, Lulu Yin, Cameron Durfee, Rommie E Amaro, Hideki Aihara
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2106379119