| Process | Activity | Enzyme | Type
 RNA virus
 DNA virus
 RT virus
 Cell | Rhea | Antiviral |
|---|---|---|---|---|---|
| Viral replication | Polymerase | RNA dependent RNA polymerase (RNA replicase) | | Rhea:21248 | Nucleoside inhibitor |
| DNA dependent DNA polymerase (DNA replicase) | | Rhea:22508 | Nucleoside inhibitor | ||
| RNA dependent DNA polymerase (Reverse transcriptase) | | Rhea:22508 | Nucleoside-RT inhibitors, Non-Nucleoside-RT inhibitors | ||
| Initiation | Primase | | |||
| Protein-primed initiation of DNA replication | | ||||
| Protein-primed initiation of RNA replication (=VPG capping) | | ||||
| Cress-type Endonuclease | | ||||
| Ribozyme Endonuclease | | ||||
| Elongation | RNA-DNA duplex dependent endoribonuclease (RNase H) | | |||
| Topology | DNA topoisomerase | | |||
| DNA ligase | | ||||
| Helicase | | ||||
| Holliday junction resolvase | | ||||
| Integrase | | ||||
| Transposase (DDE recombinase) | | ||||
| Nucleotide metabolism | Thymidine kinase | | Rhea:19129 | ||
| Thymidylate synthase | | Rhea:12104 | |||
| Thymidylate kinase | | Rhea:13517 | |||
| dUTP diphosphatase | | Rhea:10248 | |||
| dihydrofolate reductase | | Rhea:15009 | |||
| Ribonucleotide reductase | | Rhea:23252 | |||
| Regulation | E3 SUMO-protein ligase | | |||
| Viral transcription | Transcriptase | DNA dependent RNA polymerase (Transcriptase) | | Rhea:21248 | |
| RNA dependent RNA polymerase (RNA replicase/transcriptase) | | Rhea:21248 | |||
| Proofreading exoribonuclease (ExoN) | | ||||
| Viral mRNA capping | Cell-type capping | |
Rhea:67004 Rhea:67012 Rhea:67008 Rhea:67020 | ||
| Alpha type capping | | ||||
| Nido-type capping | | ||||
| Mononega-type capping | | ||||
| VPG capping | | ||||
| Cap snatching | | ||||
| Toti-type cap snatching | | ||||
| FAD capping | | ||||
| PolyAdenylation | Poly(A) polymerase | | Rhea:11332 | ||
| RNA polymerase stuttering | | Rhea:11332 | |||
| Protein | Proteases | Cys/Ser-proteases | | ||
| Asp-proteases | | ||||
| Metallo-proteases | | ||||
| Asparagine-proteases | | ||||
| Post translational modification | Beta-1,6-N-acetyl-glucosaminyl transferase | ||||
| Peptide N-myristoyl transferase | Rhea:15521 | ||||
| thiol oxidase | |||||
| Exit | Budding | Phospholipase | | ||
| Virion release | Neuraminidase | | Neuraminidase inhibitors | ||
| Viral-Host modulation | Anti-viral evasion | Polyuridine endonuclease | | ||
| Viral ADP-Ribosylhydrolase | | ||||
| Asparagine deaminase | |||||
| Ser/Thr kinase | |||||
| Tyr kinase | |||||
| Ubiquitin transferase=Ubiquitin-conjugating enzyme E2 | |||||
| ubiquitinyl hydrolase | |||||
| Tyr/ser/thr phosphatase | |||||
| 2',3'-cGAMP endonuclease | Rhea:59473 | ||||
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | |||||
| ADP-ribose hydrolase | Rhea:24076 | ||||
| Host shut off | mRNA-decapping | ||||
| Other | Trans-prenyltransferase | ||||
| Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||||
| Ribonucleoside-diphosphate reductase | |||||
| FAD-linked sulfhydryl oxidase |