Polyuridine endonuclease

Degrades the 5'-polyuridines generated during Coronavirus replication of the poly(A) region of viral genomic and subgenomic RNAs . If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails, activate host dsRNA sensors and trigger cell antiviral response. This activity is only found in vertebrate Nidovirus.

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Enzymatic reaction:

  • 2'-O transesterification generates a 2'3'-cyclic phosphate (2'3'-cP) RHEA:67792 EC=4.6.1.-
  • RNA 2',3'-cyclic 3'-phosphodiesterase RHEA:11828 EC 3.1.4.58



Domain: PF19215

Mechanism image