Inhibition of host interferon signaling pathway by virus (kw:KW-1114)
The type I interferons are cytokines produced by mammalian cells in response to virus infection. IFNs exert antiviral function by binding to the IFNalpha/beta receptors on the cell surface, and thereby activating the JAK-STAT signaling cascade. The outcome of the pathway activation is the establishment of an antiviral state in the cell characterized by the expression of hundreds interferon-stimulated genes.

Many viruses modulate the interferon signaling pathway by inhibiting the cellular proteins participating in this cascade. They can interfere with basically all the components participating in the expression of interferon-stimulated genes including STAT1, STAT2, JAK1, or TYK2.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)631 entries grouped by protein
4 entries
Protein MGF 360-9L
3 entries
Protein MGF 505-7R
1 entry
ORF3a protein (Accessory protein 3a) (Protein 3a) (Protein U274) (Protein X1)
1 entry
G-protein coupled receptor BILF1 (GPCR BILF1)
13 entries
Protein C'
3 entries
Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)
5 entries
Protein DP71L (MyD116 homolog)
8 entries
Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)
14 entries
Early E1A protein (Early E1A 20 kDa protein)
1 entry
E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
1 entry
Protein E3 homolog (Protein E3L homolog)
3 entries
Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
1 entry
E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)
3 entries
mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein EB2) (Protein SM)
5 entries
Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)
2 entries
Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
2 entries
Protein IRS1
1 entry
Protein K3 homolog
2 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
5 entries
Latent membrane protein 1 (LMP-1) (Protein p63)
20 entries
Large T antigen (LT) (LT-AG) (EC 5.6.2.4) (DNA 3'-5' helicase large T antigen)
1 entry
E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)
1 entry
E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)
3 entries
Microtubule-associated protein mu-2 (Mu2)
9 entries
Nucleoprotein (Protein N) (Nucleocapsid protein)
147 entries
Non-structural protein 1 (NS1) (NS1A)
6 entries
Non-structural protein 2 (NS2) (Non-structural protein 1B)
2 entries
ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)
4 entries
Non-structural protein NS-S (NSs)
2 entries
IFN signaling evasion protein OPG029
2 entries
Protein K3
4 entries
RNA-binding protein OPG065 (RNA-binding protein E3) (p25)
3 entries
Soluble interferon gamma receptor OPG193 (B8)
6 entries
Soluble interferon alpha/beta receptor OPG204 (S antigen)
23 entries
Phosphoprotein (Protein P) (Protein M1)
93 entries
Genome polyprotein
3 entries
Polyprotein P1234 (P1234) (Non-structural polyprotein) (p270 nonstructural polyprotein)
21 entries
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
21 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
3 entries
Accessory factor US11 (Vmw21)
7 entries
Replicase polyprotein 1ab (ORF1ab polyprotein)
3 entries
Outer capsid protein sigma-3 (Sigma3)
43 entries
Protein Tat (Transactivating regulatory protein)
2 entries
Protein HHLF1
1 entry
Protein UL145
1 entry
Tegument protein UL23
23 entries
Non-structural protein V
79 entries
Protein E7
5 entries
Uncharacterized protein C129R (pC129R) (EC 3.1.4.-)
5 entries
ERCC4 domain-containing protein EP364R (pEP364R) (EC 3.1.4.-)
3 entries
Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
1 entry
Viral IRF2-like protein (vIRF-2)
1 entry
Membrane-associated protein VP24 (Ebola VP24) (eVP24)
5 entries