Large dsDNA bacteriophages, herpesviruses, adenoviruses and microviruses encode a powerful DNA-translocating machinenery that encapsidates a viral genome into a preassembled capsid or procapsid . The packaging machine is often composed of a portal structure, which provides a gate for DNA entry, and an ATP-driven motor
. This motor is composed of the large subunit whose ATPase activity fuels DNA translocation, and most frequently, a small subunit that binds to the viral packaging site. DNA cleavage can be coupled to genome packaging
.
The ATPase of the phi29 DNA packaging motor is a member of the hexameric AAA superfamily
Chad Schwartz, Gian Marco De Donatis, Huaming Fang, Peixuan Guo
Virology August 15, 2013; 443: 20-27
Assembly of bacteriophage lambda terminase into a viral DNA maturation and packaging machine
Nasib Karl Maluf, Helene Gaussier, Elke Bogner, Michael Feiss, Carlos Enrique Catalano
Biochemistry December 26, 2006; 45: 15259-15268
The bacteriophage DNA packaging motor
Venigalla B Rao, Michael Feiss
Annu. Rev. Genet. 2008; 42: 647-681
Bacteriophage assembly
Anastasia A Aksyuk, Michael G Rossmann
Viruses March 2011; 3: 172-203
A promiscuous DNA packaging machine from bacteriophage T4
Zhihong Zhang, Vishal I Kottadiel, Reza Vafabakhsh, Li Dai, Yann R Chemla, Taekjip Ha, Venigalla B Rao
PLoS Biol. 2011; 9: e1000592
Cooperative heteroassembly of the adenoviral L4-22K and IVa2 proteins onto the viral packaging sequence DNA
Teng-Chieh Yang, Nasib Karl Maluf
Biochemistry February 21, 2012; 51: 1357-1368
A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions
Michael F Schmid, Corey W Hecksel, Ryan H Rochat, David Bhella, Wah Chiu, Frazer J Rixon
PLoS Pathog. 2012; 8: e1002961
Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions
Giovanni Cardone, J Bernard Heymann, Naiqian Cheng, Benes L Trus, Alasdair C Steven
Adv. Exp. Med. Biol. 2012; 726: 423-439
The bacteriophage DNA packaging machine
Michael Feiss, Venigalla B Rao
Adv. Exp. Med. Biol. 2012; 726: 489-509
Structure of a packaging-defective mutant of minute virus of mice indicates that the genome is packaged via a pore at a 5-fold axis
Pavel Plevka, Susan Hafenstein, Lei Li, Anthony D?Abrgamo Jr, Susan F Cotmore, Michael G Rossmann, Peter Tattersall
J. Virol. May 2011; 85: 4822-4827