Syncytium formation induced by viral infection (kw:KW-1180)

Syncytia result from the fusion of an infected cell with neighboring cells, leading to the formation of multinucleated, enlarged cells. This process is triggered by the surface expression of viral fusion proteins that are fusogenic directly at the host cell membrane.
Syncytia can only arise with viruses that are able to fuse directly at the cell surface without requiring endocytosis.

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Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Links Uniprot Keyword: KW-1180
GO ontology:GO:0060141
Virus Herpesviridae
Paramyxoviridae
Poxviridae
Reoviridae
Retroviridae

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

21 entries grouped by strain

1 entry

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

1 entry

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

GK_EHV1B Envelope glycoprotein K (Syncytial protein)

1 entry

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

GK_GAHVM Envelope glycoprotein K

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

GK_HHV11 Envelope glycoprotein K (Syncytial protein)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

GK_HHV2H Envelope glycoprotein K (Syncytial protein)

1 entry

Human respiratory syncytial virus B (strain B1) reference strain

FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening ...

1 entry

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain

GK_PSHV1 Envelope glycoprotein K (Syncytial protein)

1 entry

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

GK_VZVD Envelope glycoprotein K (Syncytial protein)

1 entry

Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

FUS_BRSVC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

pdb 5TDL

1 entry

Bovine respiratory syncytial virus (strain Rb94) (BRS)

FUS_BRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

1 entry

Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)

GK_EHV1K Envelope glycoprotein K (Syncytial protein)

1 entry

Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

GK_HHV1K Envelope glycoprotein K (Syncytial protein)

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

GK_HHV1M Envelope glycoprotein K (Syncytial protein)

1 entry

Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)

GK_HHV1R Envelope glycoprotein K (Syncytial protein)

1 entry

Human herpesvirus 1 (strain R19) (HHV-1) (Human herpes simplex virus 1)

GK_HHV19 Envelope glycoprotein K (Syncytial protein)

1 entry

Human respiratory syncytial virus

FUS_HRSV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

pdb 8T7A

1 entry

Human respiratory syncytial virus A (strain A2)

FUS_HRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

pdb 2MDP; 3IXT; 3KPE; 3O41; 3O45; 3RKI; 3RRR; 3RRT; 4CCF; 4JHW; 4MMQ; 4MMR; 4MMS; 4MMT; 4MMU; 4MMV; 4ZYP; 5C69; 5C6B; 5EA3; 5EA4; 5EA5; 5EA6; 5EA7; 5EA8; 5J3D; 5K6B; 5K6C; 5K6F; 5K6G; 5K6H; 5K6I; 5KWW; 5TOJ; 5TOK; 5TPN; 5U68; 5UDC; 5W23; 6APB; 6APD; 6CXC; 6DC3; 6DC5; 6EAD; 6EAE; 6EAF; 6EAG; 6EAH; 6EAI; 6EAJ; 6EAK; 6EAL; 6EAM; 6EAN; 6NTX; 6OE4; 6OE5; 6OJ7; 6OUS; 6VKC; 6VKD; 6VKE; 6W52; 7LUE; 7LVW; 7MMN; 7MPG; 7TN1; 8DG9; 8KG5; 8WSQ

1 entry

Human respiratory syncytial virus A (strain RSS-2)

FUS_HRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

pdb 1G2C

1 entry

Human respiratory syncytial virus B (strain 18537)

FUS_HRSV1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

pdb 6Q0S

1 entry

Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))

GK_SUHVK Envelope glycoprotein K (Syncytial protein)

1 entry

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

GK_VZVO Envelope glycoprotein K (Syncytial protein)