Feravirus (taxid:2501995)

Molecular biology

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, for a total of 12.5 kb. Encodes for five proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching .

ENZYMES

• RNA-dependent RNA polymerase [L]
• Cap Snatching endonuclease [L]

CYTOPLASMIC

1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
3. Transcription, viral mRNAs are capped in the cytoplasm.
4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
5. The ribonucleocapsids buds, presumably releasing the virion by exocytosis.