Avihepadnavirus

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins. h4. GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
  2. Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
  3. Transcription by RNA polymerase II of the pregenomic RNA (pgRNA) and subgenomic mRNAs, inducing synthesis of all the viral proteins.
  4. pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in (-)DNA covalently linked to P protein.
  5. (+)DNA synthesis from the (-)DNA template generates new RC-DNA.
  6. Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped at the ER, and new virions are released by exocytosis.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by protein (browse by keywords)

7 entries

Capsid protein (Core antigen) (Core protein) (HBcAg)

Select_allDeselect_all
CAPSD_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
CAPSD_HHBV
Heron hepatitis B virus (HHBV) reference strain
CAPSD_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)
CAPSD_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
CAPSD_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
CAPSD_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
CAPSD_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

7 entries

Protein P

Select_allDeselect_all
DPOL_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
DPOL_HHBV
Heron hepatitis B virus (HHBV) reference strain
DPOL_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)
DPOL_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
DPOL_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
DPOL_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
DPOL_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

7 entries

External core antigen (HBeAg) (Precore protein)

Select_allDeselect_all
HBEAG_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
HBEAG_HHBV
Heron hepatitis B virus (HHBV) reference strain
HBEAG_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)
HBEAG_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
HBEAG_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
HBEAG_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
HBEAG_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

7 entries

Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen)

Select_allDeselect_all
HBSAG_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV) reference strain
HBSAG_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
HBSAG_HHBV
Heron hepatitis B virus (HHBV) reference strain
HBSAG_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
HBSAG_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
HBSAG_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
HBSAG_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)