Cucumovirus

VIRION

Non-enveloped, spherical virion about 29nm in diameter with T=3 icosahedral symmetry, composed of 180 coat proteins: 12 pentamers and 20 hexamers.

GENOME

Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 3' tRNA-like structure and a 5’cap.

GENE EXPRESSION

Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins. ORF2b encodes a viral suppressor of RNA silencing (VSR) and is expressed probably as a subgenomic RNA (sgRNA4A).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Expression of protein 1a and 2a to produce replication proteins.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA4 is translated producing capsid proteins.
  7. Assembly of new virus particles.
  8. Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.

Host-virus interaction

Suppression of RNA silencing

Cucumovirus protein 2b acts as a suppressor of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

74 entries grouped by protein (browse by keywords)

All proteins are shown (view only 15 complete proteome entries)

9 entries

Replication protein 1a

Select_allDeselect_all
1A_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
1A_CMVQ
Cucumber mosaic virus (strain Q) (CMV) reference strain
1A_TAV
Tomato aspermy virus (TAV) reference strain
1A_CMVII
Cucumber mosaic virus (strain Iizuka) (CMV)
1A_CMVIX
Cucumber mosaic virus (strain Ixora) (CMV)
1A_CMVNT
Cucumber mosaic virus (strain NT9) (CMV)
1A_CMVO
Cucumber mosaic virus (strain O) (CMV)
1A_CMVY
Cucumber mosaic virus (strain Y) (CMV)
1A_PSVJ
Peanut stunt virus (strain J) (PSV)

3 entries

Suppressor of silencing 2b (Protein 2b)

Select_allDeselect_all
2B_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
2B_CMVQ
Cucumber mosaic virus (strain Q) (CMV) reference strain
2B_TAV
Tomato aspermy virus (TAV) reference strain

29 entries

Capsid protein (CP) (Coat protein)

Select_allDeselect_all
CAPSD_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
CAPSD_CMVQ
Cucumber mosaic virus (strain Q) (CMV) reference strain
CAPSD_TAV
Tomato aspermy virus (TAV) reference strain
CAPSD_CMVAS
Cucumber mosaic virus (strain As) (CMV)
CAPSD_CMVBA
Cucumber mosaic virus (strain Banana) (CMV)
CAPSD_CMVC
Cucumber mosaic virus (strain C) (CMV)
CAPSD_CMVC7
Cucumber mosaic virus (strain C7-2) (CMV)
CAPSD_CMVCS
Cucumber mosaic virus (strain CS) (CMV)
CAPSD_CMVDK
Cucumber mosaic virus (strain DKRD) (CMV)
CAPSD_CMVE5
Cucumber mosaic virus (strain E5) (CMV)
CAPSD_CMVFC
Cucumber mosaic virus (strain FC) (CMV)
CAPSD_CMVFT
Cucumber mosaic virus (strain FT) (CMV)
CAPSD_CMVI1
Cucumber mosaic virus (strain I17F) (CMV)
CAPSD_CMVII
Cucumber mosaic virus (strain Iizuka) (CMV)
CAPSD_CMVIX
Cucumber mosaic virus (strain Ixora) (CMV)
CAPSD_CMVKI
Cucumber mosaic virus (strain Kin) (CMV)
CAPSD_CMVKO
Cucumber mosaic virus (strain Kor) (CMV)
CAPSD_CMVM
Cucumber mosaic virus (strain M) (CMV)
CAPSD_CMVM4
Cucumber mosaic virus (strain M48) (CMV)
CAPSD_CMVN
Cucumber mosaic virus (strain N) (CMV)
CAPSD_CMVNT
Cucumber mosaic virus (strain NT9) (CMV)
CAPSD_CMVO
Cucumber mosaic virus (strain O) (CMV)
CAPSD_CMVP6
Cucumber mosaic virus (strain P6) (CMV)
CAPSD_CMVPE
Cucumber mosaic virus (strain Pepo) (CMV)
CAPSD_CMVS
Cucumber mosaic virus (strain S) (CMV)
CAPSD_CMVTR
Cucumber mosaic virus (strain Trk7) (CMV)
CAPSD_CMVWL
Cucumber mosaic virus (strain WL) (CMV)
CAPSD_CMVY
Cucumber mosaic virus (strain Y) (CMV)
CAPSD_PSVJ
Peanut stunt virus (strain J) (PSV)

20 entries

Movement protein (MP) (Protein 3A)

Select_allDeselect_all
MVP_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
MVP_CMVQ
Cucumber mosaic virus (strain Q) (CMV) reference strain
MVP_TAV
Tomato aspermy virus (TAV) reference strain
MVP_CMVAS
Cucumber mosaic virus (strain As) (CMV)
MVP_CMVC7
Cucumber mosaic virus (strain C7-2) (CMV)
MVP_CMVCS
Cucumber mosaic virus (strain CS) (CMV)
MVP_CMVFT
Cucumber mosaic virus (strain FT) (CMV)
MVP_CMVIX
Cucumber mosaic virus (strain Ixora) (CMV)
MVP_CMVKI
Cucumber mosaic virus (strain Kin) (CMV)
MVP_CMVKO
Cucumber mosaic virus (strain Kor) (CMV)
MVP_CMVM
Cucumber mosaic virus (strain M) (CMV)
MVP_CMVM4
Cucumber mosaic virus (strain M48) (CMV)
MVP_CMVN
Cucumber mosaic virus (strain N) (CMV)
MVP_CMVNT
Cucumber mosaic virus (strain NT9) (CMV)
MVP_CMVO
Cucumber mosaic virus (strain O) (CMV)
MVP_CMVPE
Cucumber mosaic virus (strain Pepo) (CMV)
MVP_CMVS
Cucumber mosaic virus (strain S) (CMV)
MVP_CMVTR
Cucumber mosaic virus (strain Trk7) (CMV)
MVP_CMVY
Cucumber mosaic virus (strain Y) (CMV)
MVP_PSVJ
Peanut stunt virus (strain J) (PSV)

13 entries

RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

Select_allDeselect_all
RDRP_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
RDRP_CMVQ
Cucumber mosaic virus (strain Q) (CMV) reference strain
RDRP_TAV
Tomato aspermy virus (TAV) reference strain
RDRP_CMVAS
Cucumber mosaic virus (strain As) (CMV)
RDRP_CMVB
Cucumber mosaic virus (strain B) (CMV)
RDRP_CMVII
Cucumber mosaic virus (strain Iizuka) (CMV)
RDRP_CMVIX
Cucumber mosaic virus (strain Ixora) (CMV)
RDRP_CMVK
Cucumber mosaic virus (strain K) (CMV)
RDRP_CMVKO
Cucumber mosaic virus (strain Kor) (CMV)
RDRP_CMVMB
Cucumber mosaic virus (strain MB-8) (CMV)
RDRP_CMVNT
Cucumber mosaic virus (strain NT9) (CMV)
RDRP_CMVY
Cucumber mosaic virus (strain Y) (CMV)
RDRP_PSVJ
Peanut stunt virus (strain J) (PSV)