Caliciviridae

VIRION

Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.

GENOME

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genome encodes a polyprotein (ORF1). One or two smaller ORFs are expressed from a subgenomic RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. The 3'-end terminal ORF encodes a basic protein (and the capsid protein) and is expressed through RNA termination-reinitiation.
Some Norovirus expressan alternative ORF by leaky scanning Vesiviruses are apparently unique among the Caliciviridae in that the ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Murine norovirus and rabbit hemorrhagic disease virus induce host cell apoptosis .

Host gene expression shutoff by virus

Noroviruses and Vesiviruses mediate host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

55 entries grouped by protein (browse by keywords)

All proteins are shown (view only 45 complete proteome entries)

12 entries

Capsid protein (Coat protein) (CP) (VP1)

Select_allDeselect_all
CAPSD_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Capsid protein (Coat protein) (CP)

CAPSD_NVN68
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) reference strain

Capsid protein VP1 (CP) (p59)

CAPSD_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Capsid protein (CP) (Coat protein) (VP1)

CAPSD_CACV4
Canine calicivirus (strain 48) (CaCV)
CAPSD_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)
CAPSD_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)
CAPSD_FCVF9
Feline calicivirus (strain F9) (FCV)
CAPSD_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Capsid protein (CP) (VP1)

CAPSD_RHDVR
Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)

Subgenomic capsid protein VP60

CAPSD_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)
CAPSD_SMSV4
San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)
CAPSD_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Capsid protein VP1 (CP)

21 entries

Genome polyprotein (p254)

Select_allDeselect_all
POLG_BECN1
Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain

Genome polyprotein

POLG_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Genome polyprotein

POLG_NVN68
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) reference strain

Genome polyprotein

POLG_RHDVF
Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain
POLG_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain

Genome polyprotein

POLG_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Genome polyprotein

POLG_BECNB
Bovine enteric calicivirus NB (isolate Bovine/United States/Nebraska/1980) (BEC-NB)

Genome polyprotein

POLG_CACV4
Canine calicivirus (strain 48) (CaCV)

Genome polyprotein

POLG_EBHSG
European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)
POLG_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)

Genome polyprotein

POLG_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)

Genome polyprotein

POLG_FCVF9
Feline calicivirus (strain F9) (FCV)

Genome polyprotein

POLG_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Genome polyprotein

POLG_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)

Genome polyprotein

POLG_RHDV3
Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)
POLG_RHDVA
Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)
POLG_RHDVB
Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)
POLG_RHDVS
Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)
POLG_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

Genome polyprotein

POLG_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Genome polyprotein

POLG_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Genome polyprotein

20 entries

Protein VP2 (Minor capsid protein)

Select_allDeselect_all
VP2_BECN1
Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain

Protein VP2 (Minor capsid VP2)

VP2_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain
VP2_NVN68
Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) reference strain
VP2_RHDVF
Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain
VP2_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP2_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain
VP2_BECNB
Bovine enteric calicivirus NB (isolate Bovine/United States/Nebraska/1980) (BEC-NB)
VP2_CACV4
Canine calicivirus (strain 48) (CaCV)
VP2_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)
VP2_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)
VP2_FCVF9
Feline calicivirus (strain F9) (FCV)
VP2_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)
VP2_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)
VP2_RHDV3
Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)
VP2_RHDVA
Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)
VP2_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)
VP2_SMSV4
San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)
VP2_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)
VP2_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
VP2_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

2 entries

Uncharacterized protein VP3

Select_allDeselect_all
VP3_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP3_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)