Flaviviridae

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VIRION

Enveloped, spherical, about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry.
Source: Zhang et al

GENOME

Monopartite, linear, ssRNA(+) genome of about 9.7-12 kb. The genome 3' terminus is not polyadenylated but forms a loop structure. The 5' end has a methylated nucleotide cap (to allow translation) or a genome-linked protein (VPg).

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and the viral messenger RNA. The whole genome is translated into a polyprotein, which is processed co- and post-translationally by host and viral proteases.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis or by apoptotic mimicry
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins).
  4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly occurs at the endoplasmic reticulum and seems to be facilitated by the viral ionic channel. The virion buds at the endoplasmic reticulum and is transported to the Golgi apparatus.
  7. Release of new virions by exocytosis.

Host-virus interaction

Adaptive immune response inhibition

Dengue NS1 protein inhibits host complement by binding C4 and reducing C4b deposition and C3 convertase activity. Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution. .

Apoptosis modulation

Flaviviruses NS3 induces apoptosis through host caspases activation .

Autophagy modulation

Flaviviruses NS4A and NS4B induces autophagy signaling .

Cell-cycle modulation

Hepatitis C virus induces down-regulation of the retinoblastoma tumor suppressor and G1/S host cell cycle checkpoint dysregulation .

Innate immune response inhibition

Hepatitis C virus inhibits the interferon signaling pathway by blocking the IFN receptors , STAT1 and TYK2 , whilst Dengue virus blocks STAT2
Hepatitis C virus inhibits the host IFN-mediated response by blocking host MAVS , TRAFs and TBK1-IKBKE-DDX3 complex , whilst pestiviruses N(pro) blocks host IRF-3 .

Host gene expression shutoff by virus

Hepatitis C virus activates PKR about 12h p.i. to shutoff host translation through the PKR-mediated phosphorylation of the eIF2alpha initiation factor .

Matching UniProtKB/Swiss-Prot entries

98 entries grouped by protein (browse by keywords)

All proteins are shown (view only 97 complete proteome entries)

2 entries

F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted protein) (p16) (p17)

Select_allDeselect_all
F_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
F_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)

93 entries

Genome polyprotein

Select_allDeselect_all
POLG_BVDVN
Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain
POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_YEFV1
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
POLG_ZIKV
Zika virus (strain Mr 766) (ZIKV) reference strain
POLG_ALKV
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
POLG_BANV
Banzi virus (BANV)
POLG_BUSV
Bussuquara virus (BUSV)
POLG_BVDVC
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
POLG_BVDVS
Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)
POLG_CSFVA
Classical swine fever virus (strain Alfort) (CSFV) (Hog cholera virus)
POLG_CSFVB
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
POLG_DEN1B
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_EHV
Edge Hill virus (EHV)
POLG_GBVB
Hepatitis GB virus B (GBV-B) (GB virus B)
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_ILHV
Ilheus virus (ILHV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v))
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982)
POLG_KFDV
Kyasanur forest disease virus (KFDV)
POLG_KOKV
Kokobera virus (KOKV)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_LIV
Louping ill virus (Li)
POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)
POLG_MVEV5
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
POLG_OHFV
Omsk hemorrhagic fever virus (OHFV)
POLG_POWVL
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
POLG_ROCV
Rocio virus (ROCV)
POLG_TBEVH
Tick-borne encephalitis virus (strain Hypr) (TBEV)
POLG_TBEVS
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
POLG_TBEVW
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)
POLG_WNV9
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
POLG_WSLV
Wesselsbron virus (WSLV)
POLG_YEFVA
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
POLG_YEFVC
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
POLG_YEFVE
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
POLG_YEFVF
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
POLG_YEFVI
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
POLG_YEFVN
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
POLG_YEFVT
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
POLG_YEFVU
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

3 entries

Structural polyprotein

Select_allDeselect_all
POLS_JAEV1
Japanese encephalitis virus (strain SA-14)
POLS_JAEV5
Japanese encephalitis virus (strain SA(v))
POLS_JAEVJ
Japanese encephalitis virus (strain Jaoars982)