Novirhabdovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11kb in size. Encodes for six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host apoptosis

The NV protein of VHSV has an antiapoptotic function at the early stage of the virus infection

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by protein (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

6 entries

Glycoprotein (Spike glycoprotein)

Select_allDeselect_all
GLYCO_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain
GLYCO_SHRV
Snakehead rhabdovirus (SHRV) reference strain

Glycoprotein

GLYCO_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)

Glycoprotein

GLYCO_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)
GLYCO_IHNVR
Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)
GLYCO_VHSV0
Viral hemorrhagic septicemia virus (strain 07-71) (VHSV)

Spike glycoprotein

4 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain
L_SHRV
Snakehead rhabdovirus (SHRV) reference strain
L_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)
L_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

4 entries

Matrix protein

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MATRX_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain

Matrix protein (Protein M2)

MATRX_SHRV
Snakehead rhabdovirus (SHRV) reference strain
MATRX_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)
MATRX_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

Matrix protein (Protein M2)

7 entries

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

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NCAP_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain
NCAP_SHRV
Snakehead rhabdovirus (SHRV) reference strain
NCAP_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)
NCAP_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)
NCAP_IHNVR
Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)
NCAP_VHSV0
Viral hemorrhagic septicemia virus (strain 07-71) (VHSV)
NCAP_VHSVM
Viral hemorrhagic septicemia virus (strain Makah) (VHSV)

5 entries

Non-virion protein

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NV_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain
NV_SHRV
Snakehead rhabdovirus (SHRV) reference strain
NV_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)
NV_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)
NV_IHNVR
Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)

4 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_IHNVW
Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain
PHOSP_SHRV
Snakehead rhabdovirus (SHRV) reference strain
PHOSP_HIRRV
Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)
PHOSP_IHNVO
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)