Alphacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Innate immune response inhibition

TGEV protein 7 may counteract host antiviral response, possibly by modulating PP1 activity .

Matching UniProtKB/Swiss-Prot entries

92 entries grouped by protein (browse by keywords)

All proteins are shown (view only 48 complete proteome entries)

12 entries

Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

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NCAP_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
NCAP_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
NCAP_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
NCAP_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
NCAP_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NCAP_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
NCAP_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
NCAP_CVCAK
Canine coronavirus (strain K378) (CCoV) (Canine enteric coronavirus)
NCAP_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
NCAP_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)
NCAP_CVPR8
Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)
NCAP_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)

3 entries

Non-structural protein 3 (ns3) (Accessory protein 3a)

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NS3_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
NS3_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain

Non-structural protein 3 (Protein 3) (ns3) (Accessory protein 3a)

NS3_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

5 entries

Non-structural protein 3a (ns3a) (Accessory protein 3a)

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NS3A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Non-structural protein 3a (ns3a) (Accessory protein 3a) (X2a protein)

NS3A_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NS3A_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
NS3A_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
NS3A_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)

Non-structural protein 3a (ns3a) (Accessory protein 3a) (X2a protein)

6 entries

Putative truncated non-structural protein 3b (ns3b) (Accessory protein 3b)

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NS3B_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Putative non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1) (X2b protein)

NS3B_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NS3B_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
NS3B_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)

Non-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)

NS3B_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)

Non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1) (X2b protein)

NS3B_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)

Non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1)

2 entries

Non-structural protein 3x (ns3x) (Accessory protein 3x) (ns3b)

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NS3X_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NS3X_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)

1 entry

Non-structural protein 4a (ns4a) (Accessory protein 4a)

NS4A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain

1 entry

Non-structural protein 4b (ns4b) (Accessory protein 4b)

NS4B_CVH22
Human coronavirus 229E (HCoV-229E) reference strain

9 entries

Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)

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NS7_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
NS7_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a)

NS7_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)

Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)

NS7_CVCAK
Canine coronavirus (strain K378) (CCoV) (Canine enteric coronavirus)

Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)

NS7_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)

Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)

NS7_CVFE3
Feline enteric coronavirus (strain 79-1683) (FeCoV) (FECV)

Non-structural 7a protein (ns7a) (11 kDa protein) (Accessory protein 7a)

NS7_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)
NS7_CVPR8
Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)
NS7_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)

5 entries

Non-structural protein 7b (ns7b) (Accessory protein 7b)

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NS7B_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
NS7B_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
NS7B_CVCAK
Canine coronavirus (strain K378) (CCoV) (Canine enteric coronavirus)
NS7B_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
NS7B_CVFE3
Feline enteric coronavirus (strain 79-1683) (FeCoV) (FECV)

5 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

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R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

6 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

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R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

14 entries

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

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SPIKE_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
SPIKE_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
SPIKE_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
SPIKE_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
SPIKE_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
SPIKE_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
SPIKE_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
SPIKE_CVCAK
Canine coronavirus (strain K378) (CCoV) (Canine enteric coronavirus)
SPIKE_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
SPIKE_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)
SPIKE_CVPMI
Porcine transmissible gastroenteritis coronavirus (strain Miller) (TGEV)
SPIKE_CVPR8
Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)
SPIKE_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
SPIKE_CVPRT
Porcine transmissible gastroenteritis coronavirus (strain NEB72-rt) (TGEV)

11 entries

Envelope small membrane protein (E protein) (sM protein)

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VEMP_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain

Envelope small membrane protein (E protein) (sM protein) (Protein NS4)

VEMP_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
VEMP_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
VEMP_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Envelope small membrane protein (E protein) (sM protein) (Protein NS4) (Protein X1)

VEMP_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
VEMP_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

Envelope small membrane protein (E protein) (sM protein) (Protein NS4)

VEMP_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
VEMP_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
VEMP_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)

Envelope small membrane protein (E protein) (sM protein) (Protein NS4) (Protein X1)

VEMP_CVPR8
Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)

Envelope small membrane protein (E protein) (sM protein) (ORF 3) (Protein 4) (Protein X1)

VEMP_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)

Envelope small membrane protein (E protein) (sM protein) (ORF 3) (Protein 4) (Protein X1)

12 entries

Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

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VME1_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
VME1_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
VME1_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
VME1_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
VME1_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
VME1_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
VME1_CVCAI
Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)
VME1_CVCBG
Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)
VME1_CVPFS
Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)
VME1_CVPR8
Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)
VME1_CVPRM
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
VME1_PEDVB
Porcine epidemic diarrhea virus (strain Br1/87) (PEDV)