Thogotovirus

VIRION

Enveloped, spherical. The virions are 80-120 nm in diameter

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 to 7 segments coding for 7 to 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by protein (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

2 entries

Envelope glycoprotein

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ENV_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

Envelope glycoprotein (Surface glycoprotein 75)

ENV_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

1 entry

Matrix protein 1 (M1)

M1_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

1 entry

Protein ML (ML)

ML_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

2 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

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NCAP_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
NCAP_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)

1 entry

Polymerase acidic protein (RNA-directed RNA polymerase subunit P3)

PA_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

1 entry

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PB2_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

2 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA polymerase subunit P2)

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RDRP_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
RDRP_DHVI1
Dhori virus (strain Indian/1313/61) (Dho)