Inhibition of host complement factors by virus

The complement system is a major non-specific mechanism of humoral immunity. The activation of complement involves the sequential proteolyis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response.

Members of the herpesvirus, orthopoxvirus and retrovirus families mimic or interact with complement regulatory proteins to block complement activation and neutralization of virus particles. For example, vaccinia and variola viruses encode secreted proteins that block C3(K02765:9606) convertase assembly. Influenza A virus instead blocks the complement pathway via M1(P03485) protein interacting with and inhibiting host C1qA(AF135157:9606) protein.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

All proteins are shown (view only 11 complete proteome entries)

3 entries

Capsid polyprotein VP90

Select_allDeselect_all
CAPSD_TASV1
Turkey astrovirus 1 (TAstV-1) reference strain
CAPSD_ANV1
Avian nephritis virus 1 (ANV-1)
CAPSD_TASV2
Turkey astrovirus 2 (TAstV-2)

11 entries

Envelope glycoprotein C

Select_allDeselect_all
GC_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GC_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GC_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)

GC_BHV1C
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Envelope glycoprotein C homolog (Glycoprotein GIII)

GC_EHV1D
Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_EHV4
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Envelope glycoprotein C (Glycoprotein 13)

GC_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GC_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GC_HHV2G
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein C (Glycoprotein F)

GC_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

Envelope glycoprotein C homolog (Glycoprotein GIII)

1 entry

Complement control protein (KCP)

ORF4_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Genome polyprotein

POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)

2 entries

Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)

Select_allDeselect_all
VCP_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
VCP_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain