Inhibition of host complement factors by virus

The complement system is a major non-specific mechanism of humoral immunity. The activation of complement involves the sequential proteolyis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response.

Members of the herpesvirus, orthopoxvirus and retrovirus families mimic or interact with complement regulatory proteins to block complement activation and neutralization of virus particles. For example, vaccinia and variola viruses encode secreted proteins that block C3(K02765:9606) convertase assembly. Influenza A virus instead blocks the complement pathway via M1(P03485) protein interacting with and inhibiting host C1qA(AF135157:9606) protein.

Matching UniProtKB/Swiss-Prot entries

131 entries grouped by protein (browse by keywords)

All proteins are shown (view only 76 complete proteome entries)

3 entries

Capsid polyprotein VP90

Select_allDeselect_all
CAPSD_TASV1
Turkey astrovirus 1 (TAstV-1) reference strain
CAPSD_ANV1
Avian nephritis virus 1 (ANV-1)
CAPSD_TASV2
Turkey astrovirus 2 (TAstV-2)

11 entries

Envelope glycoprotein C

Select_allDeselect_all
GC_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GC_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GC_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)

GC_BHV1C
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Envelope glycoprotein C homolog (Glycoprotein GIII)

GC_EHV1D
Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_EHV4
Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Envelope glycoprotein C (Glycoprotein 13)

GC_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GC_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GC_HHV2G
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein C (Glycoprotein F)

GC_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

Envelope glycoprotein C homolog (Glycoprotein GIII)

113 entries

Matrix protein 1 (M1)

Select_allDeselect_all
M1_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
M1_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
M1_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
M1_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
M1_I000F
Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))
M1_I000X
Influenza A virus (strain A/X-31 H3N2)
M1_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
M1_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
M1_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
M1_I01A1
Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
M1_I01A2
Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
M1_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
M1_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
M1_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
M1_I02A3
Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
M1_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
M1_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
M1_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
M1_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
M1_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
M1_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
M1_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
M1_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
M1_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
M1_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
M1_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
M1_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
M1_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
M1_I37A0
Influenza A virus (strain A/Swine/29/1937 H1N1)
M1_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
M1_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
M1_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
M1_I50A0
Influenza A virus (strain A/Fort Warren/1/1950 H1N1)
M1_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
M1_I54A1
Influenza A virus (strain A/Swine/May/1954 H1N1)
M1_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
M1_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
M1_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
M1_I56A3
Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
M1_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
M1_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
M1_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
M1_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
M1_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
M1_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
M1_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
M1_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
M1_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
M1_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
M1_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
M1_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
M1_I68A0
Influenza A virus (strain A/Aichi/2/1968 H3N2)
M1_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
M1_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
M1_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
M1_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
M1_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
M1_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
M1_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
M1_I71A2
Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)
M1_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
M1_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
M1_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
M1_I72A5
Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)
M1_I72A8
Influenza A virus (strain A/Udorn/1972 H3N2)
M1_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
M1_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
M1_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
M1_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
M1_I77A9
Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)
M1_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
M1_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
M1_I77AC
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
M1_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
M1_I77AG
Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
M1_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
M1_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
M1_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
M1_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
M1_I78AF
Influenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)
M1_I79A0
Influenza A virus (strain A/Bangkok/1/1979 H3N2)
M1_I79A6
Influenza A virus (strain A/Equine/New Market/1979 H3N8)
M1_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
M1_I79A8
Influenza A virus (strain A/Gull/Maryland/1815/1979 H13N6)
M1_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
M1_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
M1_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
M1_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
M1_I80AC
Influenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)
M1_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
M1_I81A2
Influenza A virus (strain A/Equine/Kentucky/1/1981)
M1_I81A4
Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)
M1_I82A7
Influenza A virus (strain A/Swine/Hong Kong/127/1982 H3N2)
M1_I82A9
Influenza A virus (strain A/Philippines/2/1982 H3N2)
M1_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
M1_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
M1_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
M1_I83A6
Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
M1_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
M1_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
M1_I85A4
Influenza A virus (strain A/Swine/Netherlands/12/1985 H1N1)
M1_I86A2
Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
M1_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
M1_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
M1_I88A5
Influenza A virus (strain A/Swine/Iowa/17672/1988 H1N1)
M1_I88A7
Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)
M1_I89A2
Influenza A virus (strain A/Beijing/353/1989 H3N2)
M1_I89A7
Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)
M1_I91A0
Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)
M1_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
M1_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
M1_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
M1_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

1 entry

Complement control protein (KCP)

ORF4_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Genome polyprotein

POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)

2 entries

Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)

Select_allDeselect_all
VCP_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
VCP_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain