Peribunyaviridae

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) bind to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Orthobunyavirus express alternative ORF by leaky scanning Phlebovirus and Tospovirus have ambisense segment(s).

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

26 entries grouped by protein (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

6 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
GP_BUNYW
Bunyamwera virus (BUNV) reference strain
GP_BUNGE
Bunyavirus germiston
GP_BUNL7
Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
GP_BUNSH
Bunyavirus snowshoe hare
GP_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

3 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
L_BUNYW
Bunyamwera virus (BUNV) reference strain
L_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

8 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NCAP_BUNYW
Bunyamwera virus (BUNV) reference strain
NCAP_AINOV
Aino virus
NCAP_BUNGE
Bunyavirus germiston
NCAP_BUNLC
Bunyavirus La Crosse
NCAP_BUNSH
Bunyavirus snowshoe hare
NCAP_MAGV
Maguari virus
NCAP_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

8 entries

Non-structural protein NS-S

Select_allDeselect_all
NSS_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NSS_BUNYW
Bunyamwera virus (BUNV) reference strain
NSS_AINOV
Aino virus
NSS_BUNGE
Bunyavirus germiston
NSS_BUNLC
Bunyavirus La Crosse
NSS_BUNSH
Bunyavirus snowshoe hare
NSS_MAGV
Maguari virus
NSS_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

1 entry

Putative uncharacterized 9.3 kDa protein

Y9KD_MAGV
Maguari virus