Avulavirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachment to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of antiviral signaling through STAT1

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

8 entries

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

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FUS_NDVB1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_NDVB1 Matrix protein
L_NDVB1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_NDVB1 Hemagglutinin-neuraminidase (EC 3.2.1.18)
NCAP_NDVB1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_NDVB1 Phosphoprotein (Protein P)
W_NDVB1 Protein W
V_NDVB1 Protein V

6 entries

Newcastle disease virus (strain Beaudette C/45) (NDV)

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FUS_NDVB Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_NDVB Matrix protein
HN_NDVB Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_NDVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_NDVB Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_NDVB Phosphoprotein (Protein P)

4 entries

Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

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FUS_NDVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVA Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_NDVA Matrix protein
PHOSP_NDVA Phosphoprotein (Protein P) (Non-structural protein C, 38 kDa/29 kDa)

2 entries

Newcastle disease virus (strain B1-Hitchner/47) (NDV)

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FUS_NDVH4 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVH4 Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)

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FUS_NDVU Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVU Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))

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FUS_NDVTG Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVTG Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)

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FUS_NDVL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVL Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain D26/76) (NDV)

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FUS_NDVD Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVD Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Her/33) (NDV)

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FUS_NDVH3 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVH3 Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Italien/45) (NDV)

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FUS_NDVI Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVI Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Miyadera/51) (NDV)

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FUS_NDVM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVM Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Queensland/66) (NDV)

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FUS_NDVQ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVQ Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Ulster/2C) (NDV)

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PHOSP_NDVU2 Phosphoprotein (Protein P)
V_NDVU2 Non-structural protein V

1 entry

Newcastle disease virus (isolate AF2240) (NDV)

NCAP_NDVAF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Newcastle disease virus (strain Chi/85) (NDV)

HN_NDVC Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Iba/85) (NDV)

HN_NDVJ Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Kansas) (NDV)

HN_NDVK Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Texas) (NDV)

FUS_NDVT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]