Rubulavirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by protein (browse by keywords)

All proteins are shown (view only 30 complete proteome entries)

9 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
FUS_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
FUS_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
FUS_SV41
Simian virus 41 (SV41) reference strain
FUS_MUMP1
Mumps virus (strain SBL-1) (MuV)
FUS_MUMPR
Mumps virus (strain RW) (MuV)
FUS_MUMPS
Mumps virus (strain SBL) (MuV)
FUS_PI2H
Human parainfluenza 2 virus (HPIV-2)
FUS_PI2HG
Human parainfluenza 2 virus (strain Greer) (HPIV-2)

11 entries

Hemagglutinin-neuraminidase (EC 3.2.1.18)

Select_allDeselect_all
HN_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
HN_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
HN_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
HN_SV41
Simian virus 41 (SV41) reference strain
HN_MUMP1
Mumps virus (strain SBL-1) (MuV)
HN_MUMPR
Mumps virus (strain RW) (MuV)
HN_PI2H
Human parainfluenza 2 virus (HPIV-2)
HN_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
HN_PIV5C
Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)
HN_PIV5D
Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)
HN_PIV5L
Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)

5 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
L_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
L_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
L_SV41
Simian virus 41 (SV41) reference strain
L_PIV5W
Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)

9 entries

Matrix protein

Select_allDeselect_all
MATRX_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
MATRX_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Matrix protein (Membrane protein)

MATRX_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Matrix protein (Membrane protein)

MATRX_SV41
Simian virus 41 (SV41) reference strain
MATRX_LPMV
La Piedad-Michoacan-Mexico virus (LPMV)
MATRX_MUMP1
Mumps virus (strain SBL-1) (MuV)
MATRX_MUMPS
Mumps virus (strain SBL) (MuV)
MATRX_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
MATRX_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

8 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

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NCAP_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
NCAP_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
NCAP_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
NCAP_SV41
Simian virus 41 (SV41) reference strain
NCAP_MUMP1
Mumps virus (strain SBL-1) (MuV)
NCAP_MUMPJ
Mumps virus (strain Jeryl-Lynn) (MuV)
NCAP_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
NCAP_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

10 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
PHOSP_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
PHOSP_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
PHOSP_MUMP1
Mumps virus (strain SBL-1) (MuV)
PHOSP_MUMPE
Mumps virus (strain Enders) (MuV)
PHOSP_MUMPS
Mumps virus (strain SBL) (MuV)
PHOSP_PI2H
Human parainfluenza 2 virus (HPIV-2)
PHOSP_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
PHOSP_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)
PHOSP_SV41
Simian virus 41 (SV41)

16 entries

Small hydrophobic protein

Select_allDeselect_all
SH_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
SH_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
SH_MUMP1
Mumps virus (strain SBL-1) (MuV)
SH_MUMP2
Mumps virus (strain Edingburgh 2) (MuV)
SH_MUMP4
Mumps virus (strain Edingburgh 4) (MuV)
SH_MUMP6
Mumps virus (strain Edingburgh 6) (MuV)
SH_MUMPA
Mumps virus (strain Matsuyama) (MuV)
SH_MUMPB
Mumps virus (strain Belfast) (MuV)
SH_MUMPE
Mumps virus (strain Enders) (MuV)
SH_MUMPJ
Mumps virus (strain Jeryl-Lynn) (MuV)
SH_MUMPK
Mumps virus (strain Kilham) (MuV)
SH_MUMPL
Mumps virus (strain Bristol 1) (MuV)
SH_MUMPR
Mumps virus (strain RW) (MuV)
SH_MUMPS
Mumps virus (strain SBL) (MuV)
SH_MUMPT
Mumps virus (strain Takahashi) (MuV)
SH_MUMPU
Mumps virus (strain Urabe vaccine AM9) (MuV)

10 entries

Non-structural protein V

Select_allDeselect_all
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SV41
Simian virus 41 (SV41) reference strain
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_PI2H
Human parainfluenza 2 virus (HPIV-2)
V_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)