Rubulavirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by strain (browse by keywords)

All proteins are shown (view only 30 complete proteome entries)

8 entries

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Select_allDeselect_all
FUS_MUMPM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_MUMPM Small hydrophobic protein
HN_MUMPM Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_MUMPM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_MUMPM Matrix protein
NCAP_MUMPM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MUMPM Phosphoprotein (Protein P)
V_MUMPM Non-structural protein V (Non-structural protein NS1)

8 entries

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Select_allDeselect_all
FUS_PIV5 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_PIV5 Small hydrophobic protein
HN_PIV5 Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PIV5 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_PIV5 Matrix protein (Membrane protein)
NCAP_PIV5 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PIV5 Phosphoprotein (Protein P)
V_PIV5 Non-structural protein V

7 entries

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Select_allDeselect_all
FUS_PI2HT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_PI2HT Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PI2HT RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_PI2HT Matrix protein (Membrane protein)
NCAP_PI2HT Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI2HT Phosphoprotein (Protein P)
V_PI2HT Non-structural protein V

6 entries

Simian virus 41 (SV41) reference strain

Select_allDeselect_all
FUS_SV41 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_SV41 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HN_SV41 Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_SV41 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_SV41 Matrix protein
V_SV41 Non-structural protein V

7 entries

Mumps virus (strain SBL-1) (MuV)

Select_allDeselect_all
FUS_MUMP1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_MUMP1 Small hydrophobic protein
HN_MUMP1 Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_MUMP1 Matrix protein
NCAP_MUMP1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MUMP1 Phosphoprotein (Protein P)
V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Simian virus 41 (SV41)

PHOSP_SV41 Phosphoprotein (Protein P)

5 entries

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

Select_allDeselect_all
NCAP_PI4HA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HN_PI4HA Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_PI4HA Matrix protein
PHOSP_PI4HA Phosphoprotein (Protein P)
V_PI4HA Non-structural protein V

5 entries

Mumps virus (strain SBL) (MuV)

Select_allDeselect_all
FUS_MUMPS Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_MUMPS Small hydrophobic protein
MATRX_MUMPS Matrix protein
PHOSP_MUMPS Phosphoprotein (Protein P)
V_MUMPS Non-structural protein V (Non-structural protein NS1)

4 entries

Human parainfluenza 2 virus (HPIV-2)

Select_allDeselect_all
FUS_PI2H Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_PI2H Hemagglutinin-neuraminidase (EC 3.2.1.18)
PHOSP_PI2H Phosphoprotein (Protein P)
V_PI2H Non-structural protein V

4 entries

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

Select_allDeselect_all
MATRX_PI4HB Matrix protein
NCAP_PI4HB Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI4HB Phosphoprotein (Protein P)
V_PI4HB Non-structural protein V

3 entries

Mumps virus (strain Enders) (MuV)

Select_allDeselect_all
SH_MUMPE Small hydrophobic protein
PHOSP_MUMPE Phosphoprotein (Protein P)
V_MUMPE Non-structural protein V (Non-structural protein NS1)

3 entries

Mumps virus (strain RW) (MuV)

Select_allDeselect_all
FUS_MUMPR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_MUMPR Small hydrophobic protein
HN_MUMPR Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Mumps virus (strain Jeryl-Lynn) (MuV)

Select_allDeselect_all
SH_MUMPJ Small hydrophobic protein
NCAP_MUMPJ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Human parainfluenza 2 virus (strain Greer) (HPIV-2)

FUS_PI2HG Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

La Piedad-Michoacan-Mexico virus (LPMV)

MATRX_LPMV Matrix protein

1 entry

Mumps virus (strain Belfast) (MuV)

SH_MUMPB Small hydrophobic protein

1 entry

Mumps virus (strain Bristol 1) (MuV)

SH_MUMPL Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 2) (MuV)

SH_MUMP2 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 4) (MuV)

SH_MUMP4 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 6) (MuV)

SH_MUMP6 Small hydrophobic protein

1 entry

Mumps virus (strain Kilham) (MuV)

SH_MUMPK Small hydrophobic protein

1 entry

Mumps virus (strain Matsuyama) (MuV)

SH_MUMPA Small hydrophobic protein

1 entry

Mumps virus (strain Takahashi) (MuV)

SH_MUMPT Small hydrophobic protein

1 entry

Mumps virus (strain Urabe vaccine AM9) (MuV)

SH_MUMPU Small hydrophobic protein

1 entry

Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)

HN_PIV5D Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)

HN_PIV5C Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)

HN_PIV5L Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)

L_PIV5W RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...