Ascoviridae

Molecular biology

VIRION

Virions consist of an envelope, a core, and an internal lipid membrane associated with the inner particle. Virion can be bacilliform, ovoidal or allantoid in shape, mesuring about 130 nm in diameter, by 200-400 nm in length. Contains at least 15 different proteins.

GENOME

Circular, dsDNA genome of 156-186 kb. The genome contains two tandem of inverted repeats.

GENE EXPRESSION

Encode for up to 180 open reading frames.

REPLICATION

NUCLEUS

  1. Virus attaches to host receptors.
  2. Fusion of virus membrane with the vesicle membrane occurs; DNA genome is released into the nucleus.
  3. Transcription of viral genes, replication of the DNA genome in the nucleus.
  4. Cell nucleus enlarges and ruptures.
  5. Assembly of new virions in the cytoplasm.
  6. Host cell is cleaved in cluster of virion-containing vesicles.
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
TAXONOMY Group I: dsDNA viruses
Family: Ascoviridae
Genus: Ascovirus
ETYMOLOGY Asco: from greek, “sac”. referring to virion shape.
SPECIES
Type: Spodoptera frugiperda ascovirus 1a (SfAV-1a)
Main: Trichoplusia ni ascovirus 2a (TnAV-2a)
Heliothis virescens ascovirus 3c (HvAV-3c)
Diadromus pulchellus ascovirus 4a (DpAV-4a)
REFERENCE STRAIN Spodoptera frugiperda ascovirus 1a
Sequence | Genome | Proteome
HOST Insects: mainly Noctuids
SfAV: Spodoptera species only
CELL TROPISM TnAV, HvAV, DpAV: most host tissues.
SfAV: fat body host cells

Epidemiology

GEOGRAPHY Worldwide
ASSOCIATED DISEASES Lethal disease in larvae
TRANSMISSION May be transmitted horizontally by endoparasitic wasps, displaying a symbiotic interaction with the wasp host

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by protein

Major capsid protein

Select_all Deselect_all  
CAPSD_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
CAPSD_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)
CAPSD_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Executioner caspase (EC 3.4.22.-)


CASP_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Caspase-like protein

Select_all Deselect_all  
CSPL_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)
CSPL_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

DNA polymerase (EC 2.7.7.7)

Select_all Deselect_all  
DPOL_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
DPOL_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)
DPOL_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Putative esterase (EC 3.1.1.-)

Select_all Deselect_all  
ESTE_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
ESTE_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Putative ATP-dependent RNA helicase (EC 3.6.4.13)

Select_all Deselect_all  
HELI1_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
HELI1_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)
HELI1_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Putative matrix metalloproteinase (EC 3.4.24.-)

Select_all Deselect_all  
MMP_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
MMP_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)
MMP_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Uncharacterized protein ORF11


Y011_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Uncharacterized protein ORF12


Y012_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Uncharacterized protein ORF17


Y017_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Uncharacterized protein ORF18


Y018_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Uncharacterized protein ORF42


Y042_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Uncharacterized protein ORF43

Select_all Deselect_all  
Y043_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain
Y043_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Structural protein ORF43

Uncharacterized protein ORF57


Y057_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Uncharacterized protein ORF58


Y058_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Uncharacterized protein ORF59


Y059_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Putative structural protein ORF84


Y084_SFAVASpodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Structural protein ORF142


Y142_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Putative structural protein ORF146


Y146_HVAVEHeliothis virescens ascovirus 3e (HvAV-3e)

Structural protein ORF147


Y147_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Uncharacterized protein ORF148


Y148_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Uncharacterized protein ORF149


Y149_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)

Uncharacterized protein ORF150


Y150_TNAVCTrichoplusia ni ascovirus 2c (TnAV-2c)
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