Corticoviridae

Molecular biology

VIRION

Icosahedral T=21 capsid 56 nm in diameter, composed of 1200 P1 (spike) and 60 P2 (capsid) proteins. The pentameric receptor-binding spikes are protruding from the 12 fivefold axes. The capsid encloses an internal lipid core containing the structural proteins P3 to P9.

GENOME

Circular, supercoiled dsDNA genome of about 10 kb encoding for 21 proteins. Displays a very high number of negative supercoils.

GENE EXPRESSION

The genome is organized in three operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attach to target cell
  2. Injection: viral DNA is injected in host cell cytoplasm
  3. Transcription and traduction of early genes
  4. Replication of genomic DNA via a rolling-circle mechanism
  5. Transcription and traduction of late genes
  6. Capsid proteins polymerize around a lipoprotein vesicle translocated in the cytoplasm by virion assembly factors.
  7. Genomic DNA is packaged in new virions
  8. Mature virions are released from the cell by lysis
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
TAXONOMY Group I: dsDNA viruses
Family: Corticoviridae
Genus: Corticovirus
ETYMOLOGY Cortico: from latin, “crust, bark”.
SPECIES
Type: Pseudoalteromonas phage PM2
REFERENCE STRAIN Pseudoalteromonas phage PM2
Sequence | Genome | Proteome
HOST Bacteria

Epidemiology

GEOGRAPHY
TRANSMISSION Passive diffusion through medium
ANTIVIRAL DRUGS

Matching UniProtKB/Swiss-Prot entries

21 entries grouped by protein

Major capsid protein P2 (Protein II)


CAPSD_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

pdb 2VVF  2W0C 

Uncharacterized protein Gp-a


GPA_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-b*


GPB_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-c


GPC_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-d


GPD_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-e


GPE_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-h


GPH_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-j


GPJ_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-k


GPK_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein Gp-l


GPL_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Probable replication protein P12 (EC 3.1.-.-) (Protein XII)


P12_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Transcription factor P13 (Protein XIII)


P13_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Uncharacterized protein P14 (Protein XIV)


P14_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Protein P3 (Protein III)


P3_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

pdb 2W0C 

Protein P4 (Protein IV)


P4_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Protein P5 (Protein V)


P5_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Protein P6 (Protein VI)


P6_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

pdb 2W0C 

Protein P7 (Protein VII)


P7_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Protein P8 (Protein VIII)


P8_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Protein P9 (Protein IX)


P9_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Spike protein P1 (Protein I)


SPIKE_BPPM2Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

pdb 2VVD  2VVE  2W0C 

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