Eukaryotic host translation shutoff by virus

The majority of cellular mRNAs initiate translation through the recruitment of a multisubunit translation initiation complex termed eIF4F, which consists of the cap-binding protein eIF4E, the RNA helicase eIF4A, and the adaptor protein eIF4G. eIF4G binds poly(A)-binding protein (PABP) to mediate 5’ -> 3’ communication, probably to promote efficient translation of intact correctly processed mRNAs. eIF4E binding protein 1 (eIF4E-BP1) functions as a translational repressor that limits eIF4E availability and therefore eIF4F complex formation.


Viruses have evolved ways of interacting with the host translational machinery to shutoff host gene expression. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response .
All the viruses inducing the shutoff of translation are able to continue to translate at least part of their mRNAs using non-canonical translation: IRES, Ribosome shunting, or VPG initiation. For adenoviridae, polyomaviridae and togaviridae the cellular translation shutoff takes place at the late phase of infection and ensures an optimal production of viral structural proteins.
Under stress conditions such as viral infection some cellular translation can continue when the cap-dependent translation initiation is inhibited. Expression of specific cellular proteins seems to occur through cap-independent mechanisms .

Viruses inducing host translation shutoff:

Family Virus Viral protein Shutoff strategy Viral translation ref.
Adenoviridae Adenovirus Shutoff protein 100K Inhibits eIF4G-Mnk1 and prevents EIF4E phosphorylation Ribosome shunting on late mRNAs
Bunyaviridae Bunyamwera virus Nucleoprotein Nuclear retention of PABP Viral mRNAs non polyadenylated
Caliciviridae Norovirus
Feline calicivirus
Protease 3C
Protease
PABP cleavage VPg
Feline calicivirus Protease Cleavage of eIF4G1 and eIF4G2 VPg
Dicistroviridae Cripavirus ? Dissociation of eIF4G and eIF4E IRES
Orthomyxoviridae Influenza virus ? Dephosphorylation of of eIF-4E eIF-4E independent translation of viral mRNAs
Picornaviridae Poliovirus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Protease 3C Cleavage of eIF5B IRES
Protease 3C PABP cleavage IRES
Rhinovirus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Coxsackie virus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Coxsackie virus Protease 2A,3C PABP cleavage IRES
Protease 3C Cleavage of eIF5B IRES
Encephalomyocarditis virus Protein 2A ? IRES
? Dephosphorylation of 4E-BP1 IRES
Foot-and-mouth disease virus Leader protease Cleavage of eIF4GI and eIF4GII IRES
Protease 3C Cleavage of PABP, eIF3a, eIF3b, and eIF4A IRES
Polyomaviridae SV40 Small T antigen Dephosphorylation of 4E-BP1 IRES
Reoviridae Rotavirus NSP3 Interacts with EIF4G and evicts PABP from initiation complexes. Nuclear relocalization of PABP NSP3 replaces PABP and bind the non polyAdenylated viral mRNAs
Rhabdoviridae Vesicular stomatitis virus ? Dephosphorylation of 4E-BP1 classical
Retroviridae HIV-1 Protease Cleavage of eIF4GI and PABP IRES
HTLV-1 Protease Cleavage of eIF4GI IRES
Moloney murine leukemia virus Protease Cleavage of eIF4GI and eIF4GII IRES
Togaviridae Rubella virus Capsid protein PABP sequestration classical
Sindbis virus dsRNA leading to PKR-mediated inhibition of eIF2alpha DLP
Coronaviridae SARS-CoV Nsp1 Binding to host 40S subunit Viral mRNA protected by 5’-end leader sequence
Bat-CoV Nsp1 - -
TGEV Nsp1 - -
Links Uniprot Keyword: KW-1193
GO ontology: GO:0039604

Matching UniProtKB/Swiss-Prot entries

216 entries grouped by protein (browse by keywords)

All proteins are shown (view only 177 complete proteome entries)

Protein 169


169_VACCWVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_all Deselect_all  
NCAP_BUNYWBunyamwera virus (BUNV) reference strain
NCAP_BUNL8Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NCAP_BUNGEBunyavirus germiston
NCAP_BUNLCBunyavirus La Crosse
NCAP_BUNSHBunyavirus snowshoe hare

Non-structural protein 3 (NSP3) (NCVP4) (Non-structural RNA-binding protein 34) (NS34)

Select_all Deselect_all  
NSP3_ROTSHRotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) ... reference strain
NSP3_ROT41Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus ...
NSP3_ROTH7Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
NSP3_ROTWIRotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)
NSP3_ROTRFRotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
NSP3_ROTBURotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
NSP3_ROTBNRotavirus A (strain RVA/Cow/United States/NCDV-Lincoln/1969/G6P6[1]) (RV-A) ...
NSP3_ROTW3Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus ...
NSP3_ROTH6Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
NSP3_ROTH3Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
NSP3_ROTHKRotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
NSP3_ROTHSRotavirus A (strain RVA/Human/Japan/S2/1980/G2P1B[4]) (RV-A)
NSP3_ROTHLRotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
NSP3_ROTHTRotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) ...
NSP3_ROTADRotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
NSP3_ROTHDRotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) ...
NSP3_ROTAMRotavirus A (strain RVA/Human/United States/M/1976/G3P[X]) (RV-A)
NSP3_ROTHPRotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
NSP3_ROTHWRotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
NSP3_ROTRHRotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
NSP3_ROTP5Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A ...
NSP3_ROTS4Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
NSP3_ROTS1Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain ...

Gag-Pol polyprotein (Pr160Gag-Pol)

Select_all Deselect_all  
POL_HV1MAHuman immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
POL_HV1B1Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

pdb 1A9M  1AJV  1AJX  1AXA  1BQM  1BQN  1D4H  1D4I  1D4J  1DLO  1DW6  1EBK  1EBW  1EBY  1EBZ  1EC0  1EC1  1EC2  1EC3  1EET  1G35  1GNM  1GNN  1GNO  1HAR  1HBV  1HEF  1HEG  1HIH  1HMV  1HNI  1HNV  1HOS  1HPS  1HPZ  1HQE  1HQU  1HRH  1HTE  1HTF  1HTG  1HVI  1HVK  1HVP  1HVU  1HYS  1IKV  1IKW  1IKX  1IKY  1J5O  1KJH  1MER  1MES  1MET  1MEU  1N5Y  1N6Q  1NPA  1NPV  1NPW  1QE1  1QMC  1R0A  1RDH  1RTD  1RVL  1RVM  1RVN  1RVO  1RVP  1RVQ  1RVR  1S6P  1S6Q  1S9E  1S9G  1SBG  1SUQ  1SV5  1T03  1T05  1T7K  1TV6  1TVR  1UWB  1W5V  1W5W  1W5X  1W5Y  1YT9  1ZP8  1ZPA  1ZSF  1ZSR  2AQU  2B5J  2B6A  2BAN  2BBB  2BE2  2EXF  2G69  2HB3  2HMI  2HNZ  2HS1  2HS2  2I4D  2I4U  2I4V  2I4W  2I4X  2I5J  2IAJ  2IC3  2IDW  2IEO  2JZW  2L45  2L46  2L4L  2UXZ  2UY0  2VG5  2VG6  2VG7  2X4U  2YKM  2YKN  2ZD1  2ZE2  3AVI  3BGR  3DLK  3GGA  3GGV  3GGX  3HVT  3IG1  3IRX  3IS9  3ISN  3ITH  3JSM  3JYT  3K2P  3K4V  3KLE  3KLF  3KLG  3KLH  3KLI  3NDT  3NU3  3NU4  3NU5  3NU6  3NU9  3NUJ  3NUO  3OK9  3PSU  3QAA  3QLH  3QO9  3TKG  3TKW  3TL9  3TLH  3V4I  3V6D  3V81  3ZPS  3ZPT  3ZPU  4COE  4CP7  4CPQ  4CPR  4CPS  4CPT  4CPU  4CPW  4CPX  4DG1  4G1Q  4G8G  4G8I  4G9D  4G9F  4H4M  4H4O  4I2P  4I2Q  4ICL  4ID5  4IDK  4IFV  4IFY  4IG0  4IG3  4KFB  4KKO  4KO0  4LSL  4LSN  4MFB  4O44  4O4G  4OJR  4PQU  4PUO  4PWD  4Q0B  4QAG  4R5P  4RW4  4RW6  4RW7  4RW8  4RW9  4U8W  4WE1  4YE3  4YHQ  4ZIP  4ZLS  5AGZ  5AH6  5AH7  5AH8  5AH9  5AHA  5AHB  5AHC  5BRY  5BS4  5C24  5C25  5C42  5CYM  5CYQ  5D3G  5FDL  5HBM  5HLF  5HP1  5HRO  5I3U  5I42  5J1E  5JFP  5JFU  5JG1  5TEP  5TER 

POL_HV1BRHuman immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain
POL_HV1H2Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
POL_HV193Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain
POL_HV1VIHuman immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
POL_HV1ANHuman immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain
POL_HV1MVHuman immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain
POL_HV2BEHuman immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain
POL_HTL1CHuman T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTLV2Human T-cell leukemia virus 2 (HTLV-2) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL32Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_SIVEKSimian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee ... reference strain
POL_SIVMBSimian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee ... reference strain
POL_SIVTNSimian immunodeficiency virus (isolate TAN1) (SIV-cpz) (Chimpanzee ... reference strain
POL_HV1U4Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
POL_HV1A2Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
POL_HV1B5Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)
POL_HV1JRHuman immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
POL_HV1LWHuman immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
POL_HV1MNHuman immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)
POL_HV1N5Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)
POL_HV1OYHuman immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
POL_HV1RHHuman immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
POL_HV1Y2Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
POL_HV1B9Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
POL_HV192Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
POL_HV1ETHuman immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)
POL_HV1ELHuman immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1)
POL_HV1NDHuman immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
POL_HV1Z2Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) ...
POL_HV1MPHuman immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
POL_HV1M2Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
POL_HV19NHuman immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
POL_HV1SEHuman immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
POL_HV190Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)
POL_HV1V9Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
POL_HV1S9Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
POL_HV1S2Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
POL_HV196Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) ...
POL_HV197Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) ...
POL_HV1YBHuman immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
POL_HV1YFHuman immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)
POL_HV2CAHuman immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)
POL_HV2D1Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)
POL_HV2G1Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
POL_HV2KRHuman immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)
POL_HV2NZHuman immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)
POL_HV2ROHuman immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
POL_HV2SBHuman immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)
POL_HV2STHuman immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)
POL_HV2D2Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)
POL_HV2EHHuman immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)
POL_HV2UCHuman immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)
POL_HTL1LHuman T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL1AHuman T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL3PHuman T-cell leukemia virus 3 (strain Pyl43) (HTLV-3)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_SIVCZSimian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee ...
POL_SIVS4Simian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian ...
POL_SIVGBSimian immunodeficiency virus (isolate GB1) (SIV-mnd) (Simian immunodeficiency ...
POL_SIVMKSimian immunodeficiency virus (isolate K6W) (SIV-mac) (Simian immunodeficiency ...
POL_SIVM1Simian immunodeficiency virus (isolate Mm142-83) (SIV-mac) (Simian ...
POL_SIVSPSimian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian ...
POL_SIVG1Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) ...
POL_SIVVTSimian immunodeficiency virus agm.vervet (isolate AGM TYO-1) (SIV-agm.ver) ...
POL_SIVV1Simian immunodeficiency virus agm.vervet (isolate AGM155) (SIV-agm.ver) (Simian ...
POL_SIVVGSimian immunodeficiency virus agm.vervet (isolate AGM3) (SIV-agm.ver) (Simian ...

Genome polyprotein

Select_all Deselect_all  
POLG_EMCVREncephalomyocarditis virus (strain Rueckert) (EMCV) reference strain
POLG_FCVURFeline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain
POLG_HAVHMHuman hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A ... reference strain
POLG_HRV8AHuman rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1MPoliovirus type 1 (strain Mahoney) reference strain
POLG_BOVEVBovine enterovirus (strain VG-5-27) (BEV)
POLG_CX16GCoxsackievirus A16 (strain G-10)
POLG_CX16TCoxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21Coxsackievirus A21 (strain Coe)
POLG_CXA24Coxsackievirus A24 (strain EH24/70)
POLG_CXA9Coxsackievirus A9 (strain Griggs)
POLG_CXB1JCoxsackievirus B1 (strain Japan)
POLG_CXB2OCoxsackievirus B2 (strain Ohio-1)
POLG_CXB3NCoxsackievirus B3 (strain Nancy)
POLG_CXB3WCoxsackievirus B3 (strain Woodruff)
POLG_CXB4ECoxsackievirus B4 (strain E2)
POLG_CXB4JCoxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5PCoxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6SCoxsackievirus B6 (strain Schmitt)
POLG_EC01FEchovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC11GEchovirus 11 (strain Gregory)
POLG_EC12TEchovirus 12 (strain Travis)
POLG_EC30BEchovirus 30 (strain Bastianni)
POLG_EC05NEchovirus 5 (strain Noyce)
POLG_EC06CEchovirus 6 (strain Charles)
POLG_EC09BEchovirus 9 (strain Barty)
POLG_EC09HEchovirus 9 (strain Hill)
POLG_EMCVEncephalomyocarditis virus
POLG_EMCVBEncephalomyocarditis virus (strain emc-b nondiabetogenic)
POLG_EMCVDEncephalomyocarditis virus (strain emc-d diabetogenic)
POLG_FCVC6Feline calicivirus (strain CFI/68 FIV) (FCV)
POLG_FCVF9Feline calicivirus (strain F9) (FCV)
POLG_FCVF4Feline calicivirus (strain Japanese F4) (FCV)
POLG_HE701Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71MHuman enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HE71BHuman enterovirus 71 (strain BrCr) (Ev 71)
POLG_HAVGBHuman hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A ...
POLG_HAVH2Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A ...
POLG_HAVLAHuman hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A ...
POLG_HAVMBHuman hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A ...
POLG_HAVCFHuman hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A ...
POLG_HAV88Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A ...
POLG_HAVNOHuman hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis ...
POLG_HAVJ8Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis ...
POLG_HRV14Human rhinovirus 14 (HRV-14)
POLG_HRV16Human rhinovirus 16 (HRV-16)
POLG_HRV1AHuman rhinovirus 1A (HRV-1A)
POLG_HRV1BHuman rhinovirus 1B (HRV-1B)
POLG_HRV2Human rhinovirus 2 (HRV-2)
POLG_HRV3Human rhinovirus 3 (HRV-3)
POLG_ENMGOMengo encephalomyocarditis virus
POLG_POL1SPoliovirus type 1 (strain Sabin)
POLG_POL2LPoliovirus type 2 (strain Lansing)
POLG_POL2WPoliovirus type 2 (strain W-2)
POLG_POL32Poliovirus type 3 (strain 23127)
POLG_POL3LPoliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_PEV9UPorcine enterovirus 9 (strain UKG/410/73)
POLG_HAVS2Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A ...
POLG_SVDVHSwine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVUSwine vesicular disease virus (strain UKG/27/72) (SVDV)
POLG_TMEVBTheiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)
POLG_TMEVDTheiler's murine encephalomyelitis virus (strain DA) (TMEV)
POLG_TMEVGTheiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

Gag-Pro polyprotein (Pr76Gag-Pro)

Select_all Deselect_all  
PRO_HTL1CHuman T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
PRO_HTLV2Human T-cell leukemia virus 2 (HTLV-2) reference strain
PRO_HTL32Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) reference strain
PRO_HTL1LHuman T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)
PRO_HTL1AHuman T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
PRO_HTL3PHuman T-cell leukemia virus 3 (strain Pyl43) (HTLV-3)

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_all Deselect_all  
R1A_BCHK3Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3) reference strain
R1A_BCHK4Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK9Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVHN1Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHSAHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome ... reference strain
R1A_CVM2Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_BC133Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCRP3Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBENBovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLUBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBMBovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQBovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVEMCHuman coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC)
R1A_CVHN2Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVHOCHuman coronavirus OC43 (HCoV-OC43)
R1A_CVMJHMurine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_all Deselect_all  
R1AB_BCHK3Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3) reference strain
R1AB_BCHK4Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVHN1Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHSAHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome ... reference strain
R1AB_CVM2Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_BC133Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCRP3Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBENBovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLUBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBMBovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQBovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVEMCHuman coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC)
R1AB_CVHN2Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVHOCHuman coronavirus OC43 (HCoV-OC43)
R1AB_CVMJHMurine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

Select_all Deselect_all  
SHUT_ADEG1Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus ... reference strain
SHUT_ADE12Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain
SHUT_ADE02Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
SHUT_ADEP3Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3) reference strain
SHUT_ADECCCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain ...
SHUT_ADECRCanine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 ...
SHUT_ADEGXFowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)
SHUT_ADE05Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
SHUT_ADE40Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
SHUT_ADE41Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
SHUT_ADES1Snake adenovirus serotype 1 (SnAdV-1)

Small t antigen (ST) (ST-AG)


ST_SV40Simian virus 40 (SV40) reference strain